Cellular & Preclinical Models
Cinzia Cancellieri
Technician
Specialization: Cellular and Molecular Biology, Human Induced Pluripotent Stem Cells (hiPSC), Organoid Models
Cinzia Cancellieri is a dedicated Lab Technician at IFOM, specializing in cellular and molecular biology.
Since 2018, she has focused on human induced pluripotent stem cells (hiPSC) and organoid models, contributing her expertise in generating hiPSCs from primary cells and differentiating them into cardiomyocytes and various neuronal subtypes, including cortical, Purkinje, and dopaminergic neurons.
Her proficiency extends to characterizing, banking, and differentiating hiPSCs, with a solid foundation in cell culture techniques within BSL1/BSL2 environments. Cinzia is experienced in transfections, viral vector production, flow cytometry, and advanced fluorescence microscopy.
Holding a PhD in Experimental Pathology and Neuropathology, Cinzia combines her strong research background with her technical expertise to support experimental design, laboratory organization, and the application of cutting-edge cellular modeling techniques.
PRE IFOM
- PMID: 36483536
Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties.
Vacchini A, Maffioli E, Di Silvestre D, Cancellieri C, Milanesi S, Nonnis S, Badanai S, Mauri P, Negri A, Locati M, Tedeschi G, Borroni EM. Front Mol Biosci. 2022 Nov 22;9:1060555. doi: 10.3389/fmolb.2022.1060555. eCollection 2022. PMID: 36483536 Free PMC article. - PMID: 28169300
Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells.
Mazzara PG, Massimino L, Pellegatta M, Ronchi G, Ricca A, Iannielli A, Giannelli SG, Cursi M, Cancellieri C, Sessa A, Del Carro U, Quattrini A, Geuna S, Gritti A, Taveggia C, Broccoli V. Nat Commun. 2017 Feb 7;8:14088. doi: 10.1038/ncomms14088. PMID: 28169300 Free PMC article. - PMID: 27516453
Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration.
Orellana DI, Santambrogio P, Rubio A, Yekhlef L, Cancellieri C, Dusi S, Giannelli SG, Venco P, Mazzara PG, Cozzi A, Ferrari M, Garavaglia B, Taverna S, Tiranti V, Broccoli V, Levi S. EMBO Mol Med. 2016 Oct 4;8(10):1197-1211. doi: 10.15252/emmm.201606391. Print 2016 Oct. PMID: 27516453 Free PMC article. - PMID: 34193871
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome.
Orellana DI, Santambrogio P, Rubio A, Yekhlef L, Cancellieri C, Dusi S, Giannelli SG, Venco P, Mazzara PG, Cozzi A, Ferrari M, Garavaglia B, Taverna S, Tiranti V, Broccoli V, Levi S. EMBO Mol Med. 2016 Oct 4;8(10):1197-1211. doi: 10.15252/emmm.201606391. Print 2016 Oct. PMID: 27516453 Free PMC article. - PMID: 29466734
Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson's Disease Models.
Iannielli A, Bido S, Folladori L, Segnali A, Cancellieri C, Maresca A, Massimino L, Rubio A, Morabito G, Caporali L, Tagliavini F, Musumeci O, Gregato G, Bezard E, Carelli V, Tiranti V, Broccoli V. Cell Rep. 2018 Feb 20;22(8):2066-2079. doi: 10.1016/j.celrep.2018.01.089. PMID: 29466734 Free PMC article. - PMID: 27857203
Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming.
Rubio A, Luoni M, Giannelli SG, Radice I, Iannielli A, Cancellieri C, Di Berardino C, Regalia G, Lazzari G, Menegon A, Taverna S, Broccoli V. Sci Rep. 2016 Nov 18;6:37540. doi: 10.1038/srep37540. PMID: 27857203 Free PMC article. - PMID: 31587993
Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging.
Cozzi A, Orellana DI, Santambrogio P, Rubio A, Cancellieri C, Giannelli S, Ripamonti M, Taverna S, Di Lullo G, Rovida E, Ferrari M, Forni GL, Fiorillo C, Broccoli V, Levi S. Stem Cell Reports. 2019 Nov 12;13(5):832-846. doi: 10.1016/j.stemcr.2019.09.002. Epub 2019 Oct 3. PMID: 31587993 Free PMC article. - PMID: 32957704
Control of Cytoskeletal Dynamics by β-Arrestin1/Myosin Vb Signaling Regulates Endosomal Sorting and Scavenging Activity of the Atypical Chemokine Receptor ACKR2.
Vacchini A, Cancellieri C, Milanesi S, Badanai S, Savino B, Bifari F, Locati M, Bonecchi R, Borroni EM. Vaccines (Basel). 2020 Sep 17;8(3):542. doi: 10.3390/vaccines8030542. PMID: 32957704 Free PMC article. - PMID: 28882452
AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy.
Morabito G, Giannelli SG, Ordazzo G, Bido S, Castoldi V, Indrigo M, Cabassi T, Cattaneo S, Luoni M, Cancellieri C, Sessa A, Bacigaluppi M, Taverna S, Leocani L, Lanciego JL, Broccoli V. Mol Ther. 2017 Dec 6;25(12):2727-2742. doi: 10.1016/j.ymthe.2017.08.004. Epub 2017 Aug
