IFOM Simona Polo Lab

Simona Polo Lab

Simona Polo

Simona Polo

Dr. Simona Polo, an expert in molecular and cell biology, is the director of the Molecular Machines in Signaling Pathways research program at IFOM since 2005.

Dr. Polo was born in Milan in 1968 and studied biological sciences at the University of Milan under the supervision of Prof. Daniela Ghisotti, graduating cum laude in 1991 and honorable mention. Her thesis on bacteriophage P4 received the price for the best thesis in genetics in 1991 from the AGI association.

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Molecular Machines in Signalling Pathways

Signaling networks are complex and robust, and they are based on macromolecular complexes with fine-grained structure-function modularity. At the cellular level, signaling networks are spatiotemporally regulated by post-translational modifications that render the systems highly dynamic. Our main research interest is focus on the characterization of protein complexes that are modulated by ubiquitination at the physiological and pathological levels.

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Laboratory location: Milan, Italy

Recent publications

  • Weber J, Polo S and Maspero E.
    HECT E3 Ligases: A Tale With Multiple Facets.
    Front Physiol. 2019 Apr 3;10:370. doi: 10.3389/fphys.2019.00370. eCollection 2019.
  • Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP and Sigismund S.
    Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.
    Cell Rep. 2019;27:3049-3061 e6.
  • Maspero E, Fajner V, Weber J and Polo S.
    Detection of ubiquitinated targets in mammalian and Drosophila models.
    Methods Enzymol. 2019;619:293-318.

Group members

Staff Scientist
Elena Maspero
Postdoctoral fellows
Carlos Niño
Janine Weber
Luca Menin
Valentina Fajner
Elisa Magistrati
PhD Students
Rossella Scotto di Perrottolo
Simona Sala
Vincenzo Taibi
Maestrini Giorgia
Temporary fellow
Ilaria De Simone
Former Lab members
Matteo Biancospino (Medical Advisor, Centro Medico Santagostino, Milan)
Eleonora Valentini (Quality Assurance Assistant, Sintetica SA, Mendrisio)
Michol Savio (Medical Science Manager, Bristol-Myers Squibb, Turin)
Hans-Peter Wollscheid (Post-doc, Ulrich lab, IMB, Mainz)
Nadine Wossner (Clinical Monitor, IZKS, Mainz)
Sara Mari (Post-doc, Mapelli Lab, IEO, Milan)
Wessen Maruwge (Grant Writer, IFOM, Milan)
Filippo Acconcia (Associate Professor, Università degli Studi, Rome)
Lorenza Penengo (Group Leader at University of Zurich)
Elisabetta Argenzio (Post-doc, Moolenaar Lab, NKI, Amsterdam)
Barbara Oldrini (Staff scientist, Squatrito Lab, CNIO, Madrid)
Tanja Woelk (Post-doc, Max Planck Institute of Molecular Physiology, Dortmund)
Sara Sigismund (Staff scientist, Di FIore Lab, IEO, Milan)

(update: Oct 2019)

IFOM Review

Deubiquitination enzymes in the limelight
Commentary on Simona Polo's paper published on Current Biology, by Yossi Yarden (2015)
Ubiquitin and SUMO: an hands-on experience... by the sea
Personal memories for a memorable EMBO Practical Course organized by Simona Polo, by Ronald T. Hay (2013)
Illuminating a ubiquitin transfer relay, step-by-step
Commentary on Simona Polo's paper published on Nature Structural & Molecular Biology, by Brenda A. Schulman (2013)
complete review

Press releases


In the press

Una fotografia molecolare per l'ubiquitina

2013.05.10 | Francesco Aiello

Tumori: italiana scatta fermo immagine di proteina factotum
Ansa Salute

2013.05.10 | Elisa Buson

Il fermo immagine della proteina multitasking
Ansa Scienza

2013.05.10 | Elisa Buson

Un gruppo di ricercatori dell'IFOM apre una nuova frontiera nello studio della trasduzione del segnale

2011.03.04 | Mario Bonaccorso

Simona Polo Promossa all'esame lavoro-famiglia

2011.03 | Cristina Conti

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