IFOM Stefano Piccolo Lab

Stefano Piccolo Lab

Stefano Piccolo

Stefano Piccolo

Stefano Piccolo was born in 1967, in Italy. He obtained his MSc in Biology (1991) and his Ph.D (1995) from the University of Padua, where he worked under Giorgio Bressan on the regulation and function of the extracellular matrix proteins.

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Tissue biology and tumorigenesis

In living organs, cells are in intimate contact with each other and with their microenvironment. Within tissues, cells display remarkable, and yet mysterious, “social” behaviors. Prominent examples are the ability of cells to stop proliferating (i.e., of making copies of themselves) when they start touching each other; to change their destiny to accommodate tissue needs; or to self-organize into new tissue during the repair of damaged organs. Healthy tissues can also recognize individual tumor cells and either eliminate them or "normalize" their behavior, as such taming the effect of oncogenic mutations.

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Laboratory location: Padua, Italy

Last publications

  • Yui S, Azzolin L,Maimets M, Pedersen MT,Fordham RP, Hansen SL, Larsen HL,Guiu J, Alves MRP, Rundsten CF,Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB.
    YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration.
    Cell Stem Cell (2018), 22(1):35-49.

  • Panciera T, Azzolin L, Cordenonsi M, Piccolo S.
    Mechanobiology of YAP and TAZ in physiology and disease.
    Nat Rev Mol Cell Biol (2017), 18(12):758-770.

  • Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M, Piccolo S.
    YAP/TAZ link cell mechanics to Notch signaling to control epidermal stem cell fate.
    Nat Commun (2017), 8:15206

Group members

Francesca Zanconato
Tito Panciera
Luca Azzolin
Michelangelo Cordenonsi

(update: May 2018)