IFOM Vincenzo Costanzo Lab

Vincenzo Costanzo Lab

Vincenzo Costanzo

Italian, born in Naples in '73, Vincenzo Costanzo directs the DNA Metabolism research program at IFOM.
In 1998, he graduated in Medicine and Surgery at the University of Naples Federico II. His college years were crucial for laying the foundations of his scientific career. read more

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DNA Metabolism

Cells respond to DNA damage and replication stress, by activating a multi-faceted response called DNA damage response. In contrast to lower eukaryotes many genes involved in DNA repair and in DNA damage response are lethal when inactivated in mammalian cells even in the absence of apparent DNA damage.read more

Laboratory location: Milan, Italy

Recent publications

  • Srinivasan M, Scheinost JC, Petela NJ, Gligoris TG, Wissler M, Ogushi S, Collier JE, Voulgaris M, Kurze A, Chan KL, Hu B, Costanzo V, Nasmyth KA.
    The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.
    Cell. 2018 Apr 30. pii: S0092-8674(18)30508-7. doi: 10.1016/j.cell.2018.04.015. [Epub ahead of print]
    PMID: 29754816

  • Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P.br /> SAMHD1 acts at stalled replication forks to prevent interferon induction.
    Nature. 2018 May;557(7703):57-61. doi: 10.1038/s41586-018-0050-1. Epub 2018 Apr 18.
    PMID: 29670289

  • Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang JW, Madubata C, Anand R, Levy B, Rabadan R, Cejka P, Costanzo V, Ciccia A.
    Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
    Mol Cell. 2017 Oct 19;68(2):414-430.e8. doi: 10.1016/j.molcel.2017.09.036.
    PMID: 29053959

Group members

Staff Scientist
Anna De Antoni
Federica Pezzimenti
Post doc
Falbo Lucia
Post Doc - Guest
Santorelli Lucia
PhD student
El Kai Christelle
El Kharef Catiana
Gnocchi Andrea
Mann Anjali
Papagudi Rajagopal
Ramirez Otero Miguel Angel
Wijesekara Hanthi Yodhara Udshani
Undergraduate Student
Hanin Chmes

(update: Jan 2022)

In the press

Nobel Chimica: esperti, da studi nuovo approccio contro il cancro


La Molecola che si ripara da sola

2015.10.08  | URL

Il Nobel ai meccanici del DNA
Il Messaggero

2015.10.08 | Carla Massi

L'origine della Microcefalia


Microcefalia: ecco la proteina che regola lo sviluppo del cervello


view all press review