Giorgio Scita Lab

Giorgio Scita

A cell biologist and expert on the dynamics of cell movement, Giorgio Scita directs the Mechanisms of Tumor Cell Migration research unit at IFOM.
Born in 1963 near Parma, Scita enrolled in the Faculty of Biology at the University of Parma in 1982 with a precise intention: to study animal behavior alongside the famous Italian ethologist Danilo Mainardi.
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Mechanisms of Tumor Cell Migration

The pathophysiology of tissue fluidification: the early steps of carcinogenesis are the processes by which locally confined epithelial malignancy progressively evolves into invasive cancer. These processes are associated with the acquisition of cell motility and disrupted cell and tissue organization and dynamics, fostered by a mechanical shift from a solid-like to a liquid-like state
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Laboratory location: Milan, Italy

Recent publications

Frittoli E, Palamidessi A, Iannelli F, Zanardi F, Villa S, Barzaghi L, Abdo H, Cancila V, Beznoussenko GV, Della Chiara G, Pagani M, Malinverno C, Bhattacharya D, Pisati F, Yu W, Galimberti V, Bonizzi G, Martini E, Mironov AA, Gioia U, Ascione F, Li Q, Havas K, Magni S, Lavagnino Z, Pennacchio FA, Maiuri P, Caponi S, Mattarelli M, Martino S, d'Adda di Fagagna F, Rossi C, Lucioni M, Tancredi R, Pedrazzoli P, Vecchione A, Petrini C, Ferrari F, Lanzuolo C, Bertalot G, Nader G, Foiani M, Piel M, Cerbino R, Giavazzi F, Tripodo C, Scita G.
Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer.
Nat Mater. 2022 Dec 29. doi: 10.1038/s41563-022-01431-x. Online ahead of print.PMID: 36581770

Nader GPF, Agüera-Gonzalez S, Routet F, Gratia M, Maurin M, Cancila V, Cadart C, Palamidessi A, Ramos RN, San Roman M, Gentili M, Yamada A, Williart A, Lodillinsky C, Lagoutte E, Villard C, Viovy JL, Tripodo C, Galon J, Scita G*, Manel N*, Chavrier P*, Piel M*.
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion.
Cell. 2021 Sep 30;184(20):5230-5246.e22
* Equal Contribution

Palamidessi, A., C. Malinverno, E. Frittoli, S. Corallino, E. Barbieri, S. Sigismund, G.V. Beznoussenko, E. Martini, M. Garre, I. Ferrara, C. Tripodo, F. Ascione, E.A. Cavalcanti-Adam, Q. Li, P.P. Di Fiore, D. Parazzoli, F. Giavazzi, R. Cerbino, and G. Scita. 2019.
Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.
Nature Materials. 2019 Jul 22. doi: 10.1038/s41563-019-0425-1