IFOM Giorgio Scita Lab

Giorgio Scita Lab

Giorgio Scita

A cell biologist and expert on the dynamics of cell movement, Giorgio Scita directs the Mechanisms of Tumor Cell Migration research unit at IFOM.
Born in 1963 near Parma, Scita enrolled in the Faculty of Biology at the University of Parma in 1982 with a precise intention: to study animal behavior alongside the famous Italian ethologist Danilo Mainardi.
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Mechanisms of Tumor Cell Migration

The ability of multicellular tissue to alter their phenotypic and morphological characteristics, known as cellular plasticity, is critical in development, but also frequently exploited in adult life, such as during wound repair or de novo tissue vascularization, or in pathological situations, first and foremost during tumor dissemination.
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Laboratory location: Milan, Italy

Recent publications

  • Nader GPF, Agüera-Gonzalez S, Routet F, Gratia M, Maurin M, Cancila V, Cadart C, Palamidessi A, Ramos RN, San Roman M, Gentili M, Yamada A, Williart A, Lodillinsky C, Lagoutte E, Villard C, Viovy JL, Tripodo C, Galon J, Scita G*, Manel N*, Chavrier P*, Piel M*
    Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion.
    Cell. 2021 Sep 30;184(20):5230-5246.e22 * Equal Contribution
  • Bisi, S., S. Marchesi, A. Rizvi, D. Carra, G.V. Beznoussenko, I. Ferrara, G. Deflorian, A. Mironov, G. Bertalot, F. Pisati, A. Oldani, A. Cattaneo, G. Saberamoli, S. Pece, G. Viale, A. Bachi, C. Tripodo, G. Scita*, and A. Disanza. 2020
    IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules.
    Nat Commun. 11:3516* Corresponding author
  • Palamidessi, A., C. Malinverno, E. Frittoli, S. Corallino, E. Barbieri, S. Sigismund, G.V. Beznoussenko, E. Martini, M. Garre, I. Ferrara, C. Tripodo, F. Ascione, E.A. Cavalcanti-Adam, Q. Li, P.P. Di Fiore, D. Parazzoli, F. Giavazzi, R. Cerbino, and G. Scita. 2019
    Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.
    Nature Materials. 2019 Jul 22. doi: 10.1038/s41563-019-0425-1
  • Corallino S, Malinverno C, Neuman B, Tischer C, Palamidessi A, Frittoli E, Panagiotakopoulou M, Disanza A, Malet-Engra G, Nastaly P, Galli C, Luise C, Bertalot G, Pece S, Di Fiore PP, Gauthier NC, Ferrari A, Maiuri P, Scita G (2018)
    A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.
    Nature communications. 2018 In press

Group members

Monica Corada
Emanuela Frittoli
Staff Scientist
Andrea Disanza
Andrea Palamidessi
Post Doc
Green Brenda
Post Doc - Guest
Abdo Hind
Marchesi Stefano
Phd Student
Barzaghi Leonardo

(update: Apr 2022)

IFOM Review

Breaking up is hard to do: role of an endocytic adaptor protein in epithelial cell cohesion and breast tumor metastasis
Commentary on Giorgio Scita's paper published in Developmental Cell, by Andrew Craig (2014)
On the fast track to invasion: intracellular trafficking drives tumor metastasis
Commentary on Giorgio Scita's paper published on Journal of Cell Biology, by Stefan Linder (2014)
YouScientist: a live research program for science conscious citizens
The first year of the new IFOM Science & Society program , by Giorgio Scita (2013)
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In the press

Le cellule tumorali si muovono come stormi migratori

Corriere della Sera | Giovanni Caprara

Tumori e Matematica

2015.04.12  | Enrico Orzes

Gli scienziati rispondono
Il Corriere della Sera

2013.09.27 | Giovanni Caprara

La proteina che paralizza le difese immunitarie


Le turbo du système immunitaire


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