IFOM Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna, Ph.D. is a cell and molecular biologist that studies the involvement of the DNA damage response (DDR) pathways in physiologically-relevant processes such as aging and cancer.
Fabrizio studied Biology at the University of Trieste and obtained his Ph.D. in Molecular Genetics at SISSA, the International School for Advanced Studies, in Trieste, Italy, while working at ICGEB (International Centre for Genetic Engineering and Biotechnology) under the guidance of Mauro Giacca and Arturo Falaschi. read more

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DNA Damage Response and Cellular Senescence

We study the physiological consequences of DNA damage at the cellular and organismal level mainly in mammals. Nuclear DNA damage triggers a signaling and effector pathway known as the DNA damage response (DDR) that coordinates cell-cycle arrest (checkpoint functions) and DNA repair. read more about the program

Laboratory location: Milan, Italy

Recent publications

  1. Valentina Buemi, Odessa Schillaci, Mariangela Santorsola, Deborah Bonazza, Pamela Veneziano Broccia, Annie Zappone, Cristina Bottin, Giulia Dell’Omo, Sylvie Kengne, Stefano Cacchione, Grazia Daniela Raffa, Silvano Piazza, Fabrizio d’Adda di Fagagna, Roberta Benetti, Maurizio Cortale, Fabrizio Zanconati, Giannino Del Sal & Stefan Schoeftner
    TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance
    Nature Communications volume 13, Article number: 2302 (2022)

  2. Francesca Rossiello, Diana Jurk, João F. Passos & Fabrizio d’Adda di Fagagna
    Telomere dysfunction in ageing and age-related diseases
    Nature Cell Biology volume 24, pages 135–147 (2022)

  3. Dan Chen, Judit Z. Gervai, Ádám Póti, Eszter Németh, Zoltán Szeltner, Bernadett Szikriszt, Zsolt Gyüre, Judit Zámborszky, Marta Ceccon, Fabrizio d’Adda di Fagagna, Zoltan Szallasi, Andrea L. Richardson& Dávid Szüts
    BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1
    Nat Commun 13, 226 (2022). doi: 10.1038/s41467-021-27872-7

  4. Francesco Napoletano,Gloria Ferrari Bravo,Ilaria Anna Pia Voto,Aurora Santin,Lucia Celora,Elena Campaner, Clara Dezi, Arianna Bertossi, Elena Valentino, Mariangela Santorsola, Alessandra Rustighi, Valentina Fajner, Elena Maspero,Federico Ansaloni,Valeria Cancila, Cesare Fabio Valenti,Manuela Santo, Osvaldo Basilio Artimagnella, Sara Finaurini, Ubaldo Gioia,Simona Polo,Remo Sanges,Claudio Tripodo,Antonello Mallamaci, Stefano Gustincich, Fabrizio d’Adda di Fagagna, Fiamma Mantovani, Valeria Specchia,Giannino Del Sal
    The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
    Cell Rep.2021 Sep 14;36(11):109694. doi: 10.1016/j.celrep.2021.109694.

  5. Sara Sepe, Francesca Rossiello, Valeria Cancila, Fabio Iannelli, Valentina Matti, Giada Cicio, Matteo Cabrini, Eugenia Marinelli, Busola R Alabi, Alessia di Lillo, Arianna Di Napoli, Jerry W Shay, Claudio Tripodo, Fabrizio d'Adda di Fagagna
    DNA damage response at telomeres boosts the transcription of SARS-!CoV-2 receptor ACE2 during aging
    EMBO Rep. 2021 Dec 2;e53658. doi: 10.15252/embr.202153658. Online ahead of print.

Group members

Staff Scientist
Rossiello Francesca
Sepe Sara
Lab Technician
Do Espirito Santo Henriques Ana Cristina
Post Doc
Cabrini Matteo
Ceccon Marta
Conte Matilde
De Polo Anna
Di Lillo Alessia
Falcinelli Marta
Gioia Ubaldo
Mancheno Ferris Alexandra
Okita Akiko
Oppezzo Alessia
Tavella Sara
Post Doc - Guest
Francia Sofia
PhD Student
Rosso Ilaria
Trastus Lucrezia
Guest researcher
Eugenia Marinelli
Research Tecnichian Fellow
Boggio Sara
Cicio Giada Lucia

Former members
Flavia Michelini (Associate Director Astrazeneca)
Marek Adamowicz (Postdoc at University of Sussex, Brighton, UK)
Julio Aguado (Postdoc at the Australian Institute for Bioengineering
and Nanotechnology,
University of Queensland - Brisbane, Australia)

Aurora Cerutti (Senior Scientist at Artios Pharma, Cambridge UK)
Giuseppina D'Alessandro (Postdoc at the University of Cambridge)
Raffaella Di Micco (Principal Investigator at San Raffaele Telethon Institute for Gene Therapy)
Miriana Dobreva (Sanofi)
Matteo Formenti (Technician at Ludwig Institute for Cancer Research, Brussels, Belgium)
Marzia Fumagalli (Head of Technology Transfer Office at IEO)
Alessandro Galbiati (Senior Scientist II - Team Leader Cell based assay development and screening at Artios)
Fabio Iannelli (Bioinformatician at IFOM)
Muege Ogrunc (CSO at Stark Labs)
Fabio Pessina (Senior Research Technician at Human Technopole)
Leonid Schneider
Marie Sgandurra (Lab scientist, Université de Lausanne, CH)
Sheetal Sharma (Assistant Professor, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Sciences, Chandigarh, India )
Lucia Spath (Italian Coast Guard Officer)
Gabriele Sulli (Assistant Professor, Scintillon Institute, San Diego California)
Jelena Vermezovic (Postdoc in IFOM)
Valerio Vitelli

(update: Apr 2022)

IFOM Review

DNA: in telomeres lesions of time are inevitable
Commentary on Fabrizio d'Adda di Fagagna's paper published on Nature Cell Biology, by Leonard Hayflick (2012)
Dark matter of the genome, a safeguard of genetic integrity
Commentary on Fabrizio d'Adda di Fagagna's paper published on Nature, by Geneviève Almouzni & Antonin Morillon (2013)
complete review

In the press

Italians find molecules that block cell aging
2017.03.09

We The Italians

Covid perché fa male agli anziani?
2021.12.23

Viversani e belli

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Media