IFOM Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna, Ph.D. is a cell and molecular biologist that studies the involvement of the DNA damage response (DDR) pathways in physiologically-relevant processes such as aging and cancer.
Fabrizio studied Biology at the University of Trieste and obtained his Ph.D. in Molecular Genetics at SISSA, the International School for Advanced Studies, in Trieste, Italy, while working at ICGEB (International Centre for Genetic Engineering and Biotechnology) under the guidance of Mauro Giacca and Arturo Falaschi. read more

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DNA Damage Response and Cellular Senescence

We study the physiological consequences of DNA damage at the cellular and organismal level mainly in mammals. Nuclear DNA damage triggers a signaling and effector pathway known as the DNA damage response (DDR) that coordinates cell-cycle arrest (checkpoint functions) and DNA repair. read more about the program

Laboratory location: Milan, Italy

Recent publications

  1. Julio Aguado, Fabrizio d'Adda di Fagagna, Ernst Wolvetang
    Telomere transcription in ageing
    Ageing Res Rev. 2020 Jun 18;62:101115. doi: 10.1016/j.arr.2020.101115. Online ahead of print.

  2. Julio Aguado, Agustin Sola-Carvajal, Valeria Cancila, Gwladys Revêchon, Peh Fern Ong, Corey Winston Jones-Weinert, Emelie Wallén Arzt, Giovanna Lattanzi, Oliver Dreesen, Claudio Tripodo, Francesca Rossiello, Maria Eriksson & Fabrizio d'Adda di Fagagna
    Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
    Nature Communications volume 10, Article number: 4990 (2019)

  3. Fabio Pessina, Fabio Giavazzi, Yandong Yin, Ubaldo Gioia, Valerio Vitelli, Alessandro Galbiati, Sara Barozzi, Massimiliano Garrè, Amanda Oldani, Andrew Flaus, Roberto Cerbino, Dario Parazzoli, Eli Rothenberg and Fabrizio d'Adda di Fagagna
    Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
    Nature Cell Biology volume 21, pages1286–1299 (2019)

  4. Ubaldo Gioia, Sofia Francia, Matteo Cabrini, Silvia Brambillasca, Flavia Michelini, Corey W. Jones-Weinert and Fabrizio d'Adda di Fagagna
    Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs.
    Scientific Reports 9, Article number: 6460 (2019)

  5. Flavia Michelini, Francesca Rossiello, Fabrizio d'Adda di Fagagna and Sofia Francia
    RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci
    Nature Protocols (2019) - Published: 08 April 2019

Group members

Post doc
Matteo Cabrini
Marta Ceccon
Sofia Francia
Ubaldo Gioia
Akiko Okita
Francesca Rossiello
Sara Sepe
Giulia Dell'Omo
PhD Students
Alessia di Lillo
Corey Jones-Weinert
Ilaria Rosso
Sara Tavella
Technician/Lab manager
Valentina Matti
Claudia D'Urso

Former members
Marek Adamowicz (Postdoc at University of Sussex, Brighton, UK)
Julio Aguado (Postdoc at the Australian Institute for Bioengineering
and Nanotechnology,
University of Queensland - Brisbane, Australia)

Aurora Cerutti (Senior Scientist at Artios Pharma, Cambridge UK)
Giuseppina D'Alessandro (Postdoc at the University of Cambridge)
Raffaella Di Micco (Principal Investigator at San Raffaele Telethon Institute for Gene Therapy)
Miriana Dobreva (Sanofi)
Matteo Formenti (Technician at Ludwig Institute for Cancer Research, Brussels, Belgium)
Marzia Fumagalli (Head of Technology Transfer Office at IEO)
Alessandro Galbiati (Senior Scientist at the AstraZeneca IMED Oncology , Bioscience DNA Damage Response Group, Little Chesterford, Saffron Walden, UK )
Fabio Iannelli (Bioinformatician at IFOM)
Flavia Michelini (Research Associate Memorial Sloan Kettering Cancer Center, New York)
Muege Ogrunc (CSO at Stark Labs)
Fabio Pessina (postdoc in Ylli Doksani group in IFOM)
Leonid Schneider
Marie Sgandurra (Lab scientist, Université de Lausanne, CH)
Sheetal Sharma (Assistant Professor, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Sciences, Chandigarh, India )
Lucia Spath (Italian Coast Guard Officer)
Gabriele Sulli (Assistant Professor, Scintillon Institute, San Diego California)
Jelena Vermezovic (Postdoc in IFOM)
Valerio Vitelli

(update: Mar 2020)

IFOM Review

DNA: in telomeres lesions of time are inevitable
Commentary on Fabrizio d'Adda di Fagagna's paper published on Nature Cell Biology, by Leonard Hayflick (2012)
Dark matter of the genome, a safeguard of genetic integrity
Commentary on Fabrizio d'Adda di Fagagna's paper published on Nature, by Geneviève Almouzni & Antonin Morillon (2013)
complete review

In the press

Nell'Alzheimer il "crac" del Dna
La Stampa - Tutto Scienze e Tecnologia

2015.03.25 | Stefano Rizzato

Addio illusioni. C'è un algoritmo che sa la nostra vera età
La Stampa - Tutto Scienze e Tecnologia
2014.04.23 | Daniele Banfi
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