IFOM Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna, Ph.D. is a cell and molecular biologist that studies the involvement of the DNA damage response (DDR) pathways in physiologically-relevant processes such as aging and cancer.
Fabrizio studied Biology at the University of Trieste and obtained his Ph.D. in Molecular Genetics at SISSA, the International School for Advanced Studies, in Trieste, Italy, while working at ICGEB (International Centre for Genetic Engineering and Biotechnology) under the guidance of Mauro Giacca and Arturo Falaschi. read more

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DNA Damage Response and Cellular Senescence

We study the physiological consequences of DNA damage at the cellular and organismal level mainly in mammals. Nuclear DNA damage triggers a signaling and effector pathway known as the DNA damage response (DDR) that coordinates cell-cycle arrest (checkpoint functions) and DNA repair. read more about the program

Laboratory location: Milan, Italy

Recent publications

  1. Anna K. Uryga, Mandy O. J. Grootaert, Abel M. Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d’Adda di Fagagna, Dimitra Aravani, Helle F. Jorgensen & Martin R. Bennett
    Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury
    Communications Biology volume 4, Article number: 611 (2021)

  2. Matteo Cabrini, Marco Roncador, Alessandro Galbiati, Lina Cipolla, Antonio Maffia, Fabio Iannelli, Simone Sabbioneda, Fabrizio d'Adda di Fagagna, Sofia Francia
    DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining
    J Cell Sci. 2021 Mar 22;134(6):jcs249706. doi: 10.1242/jcs.249706.

  3. Elisa Mentegari, Federica Bertoletti, Miroslava Kissova, Elisa Zucca, Silvia Galli, Giulia Tagliavini, Anna Garbelli, Antonio Maffia, Silvia Bione, Elena Ferrari, Fabrizio d’Adda di Fagagna, Sofia Francia, Simone Sabbioneda, Liuh-Yow Chen, Joachim Lingner, Valerie Bergoglio, Jean-Sébastien Hoffmann, Ulrich Hübscher, Emmanuele Crespan, and Giovanni Maga
    A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres
    Int. J. Mol. Sci. 2021, 22(5), 2365

  4. Sheetal Sharma, Roopesh Anand, Xuzhu Zhang, Sofia Francia, Flavia Michelini, Alessandro Galbiati, Hannah Williams, Daryl A Ronato, Jean-Yves Masson, Eli Rothenberg, Petr Cejka, Fabrizio d'Adda di Fagagna
    MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
    Cell Rep. 2021 Jan 5;34(1):108565. doi: 10.1016/j.celrep.2020.108565.

  5. Ilaria Rosso, Fabrizio d'Adda di Fagagna
    Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR
    Int J Mol Sci. 2020 Dec 21;21(24):9774. doi: 10.3390/ijms21249774.

  6. Raffaella Di Micco, Valery Krizhanovsky, Darren Baker & Fabrizio d'Adda di Fagagna
    Cellular senescence in ageing: from mechanisms to therapeutic opportunities
    Nature Reviews Molecular Cell Biology (2020)

  7. Fabio Pessina, Ubaldo Gioia, Ornella Brandi, Stefania Farina, Marta Ceccon, Sofia Francia, Fabrizio d’Adda di Fagagna
    DNA Damage Triggers a New Phase in Neurodegeneration
    Trends Genet. 2020 Oct 2;S0168-9525(20)30242-0. doi: 10.1016/j.tig.2020.09.006. Online ahead of print.

Group members

Staff Scientist
Rossiello Francesca
Valentina Matti
Post Doc
Ceccon Marta
Conte Matilde
De Polo Anna
Gioia Ubaldo
Jones-Weinert Corey
Okita Akiko
Sepe Sara
Post Doc - Guest
Cabrini Matteo
Francia Sofia
PhD Student
di Lillo Alessia
Rosso Ilaria
Tavella Sara
Trastus Lucrezia
Guest researcher
Eugenia Marinelli
Research Tecnichian Fellow
Boggio Sara
Cicio Giada Lucia

Former members
Marek Adamowicz (Postdoc at University of Sussex, Brighton, UK)
Julio Aguado (Postdoc at the Australian Institute for Bioengineering
and Nanotechnology,
University of Queensland - Brisbane, Australia)

Aurora Cerutti (Senior Scientist at Artios Pharma, Cambridge UK)
Giuseppina D'Alessandro (Postdoc at the University of Cambridge)
Raffaella Di Micco (Principal Investigator at San Raffaele Telethon Institute for Gene Therapy)
Miriana Dobreva (Sanofi)
Matteo Formenti (Technician at Ludwig Institute for Cancer Research, Brussels, Belgium)
Marzia Fumagalli (Head of Technology Transfer Office at IEO)
Alessandro Galbiati (Senior Scientist II - Team Leader Cell based assay development and screening at Artios)
Fabio Iannelli (Bioinformatician at IFOM)
Flavia Michelini (Research Associate Memorial Sloan Kettering Cancer Center, New York)
Muege Ogrunc (CSO at Stark Labs)
Fabio Pessina (Senior Research Technician at Human Technopole)
Leonid Schneider
Marie Sgandurra (Lab scientist, Université de Lausanne, CH)
Sheetal Sharma (Assistant Professor, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Sciences, Chandigarh, India )
Lucia Spath (Italian Coast Guard Officer)
Gabriele Sulli (Assistant Professor, Scintillon Institute, San Diego California)
Jelena Vermezovic (Postdoc in IFOM)
Valerio Vitelli

(update: Nov 2021)

IFOM Review

DNA: in telomeres lesions of time are inevitable
Commentary on Fabrizio d'Adda di Fagagna's paper published on Nature Cell Biology, by Leonard Hayflick (2012)
Dark matter of the genome, a safeguard of genetic integrity
Commentary on Fabrizio d'Adda di Fagagna's paper published on Nature, by Geneviève Almouzni & Antonin Morillon (2013)
complete review

In the press

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