Alberto Bardelli, a molecular geneticist and expert in the field of personalized therapies, has been the Scientific Director of IFOM since 2022. He also leads the Genomics of Cancer and Targeted Therapies Unit and is Full Professor at the University of Turin. read more
Contact the researcherIn the past 15 years it has become clear that cancer has a genetic basis and that mutations affecting the coding sequences of specific genes are the hallmark of this disease. This knowledge has already had a dramatic impact in the clinical arena. read more
Tumor ‘Age’ in Early-Onset Colorectal Cancer.
Mauri G, Patelli G, Crisafulli G, Siena S, Bardelli A.
Cell. 2025 [In press]
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities.
Russo M, Misale S, Wei G, Siravegna G, Crisafulli G, Lazzari L, Corti G, Rospo G, Novara L, Mussolin B, Bartolini A, Cam N, Patel R, Yan S, Shoemaker R, Wild R, Di Nicolantonio F, Sartore-Bianchi A, Li G, Siena S, Bardelli A.
Nat Rev Cancer. 2024 Oct;24(10):694-717.
Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells.
Sogari A, Rovera E, Grasso G, Mariella E, Reilly NM, Lamba S, Mauri G, Durinikova E, Vitiello PP, Lorenzato A, Avolio M, Piumatti E, Bonoldi E, Aquilano MC, Arena S, Sartore-Bianchi A, Siena S, Trusolino L, Donalisio M, Russo M, Di Nicolantonio F, Lembo D, Bardelli A.
Cell Rep Med. 2024 Feb 20;5(2):101376.
Precision oncology for KRASG12C-mutant colorectal cancer.
Di Nicolantonio F, Bardelli A.
Nat Rev Clin Oncol. 2023 Jun;20(6):355-356.
Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance.
Amodio V, Lamba S, Chilà R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchiò C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A.
Cancer Cell. 2023 Jan 9;41(1):196-209.
Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.
Sartore-Bianchi A, Pietrantonio F, Lonardi S, Mussolin B, Rua F, Crisafulli G, Bartolini A, Fenocchio E, Amatu A, Manca P, Bergamo F, Tosi F, Mauri G, Ambrosini M, Daniel F, Torri V, Vanzulli A, Regge D, Cappello G, Marchiò C, Berrino E, Sapino A, Marsoni S, Siena S, Bardelli A.
Nat Med. 2022 Aug;28(8):1612-1618.