Giuseppe Leuzzi Lab
Giuseppe Leuzzi
Hailing from Lecce, Giuseppe studied Molecular and Cell Biology at the University of Rome Tor Vergata. After earning his BSc, he completed an MSc with honors, conducting research in the lab of Prof. Giovanni Cesareni, where he investigated the dynamics of autophagic flux and gained early expertise in molecular genetics. read more
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Functional Genomics of Cancer Immunity
The immune system plays a pivotal role in protecting the body from cancer by identifying and eliminating tumor cells. However, as tumors evolve, they accumulate mutations and chromosomal alterations that reshape their ability to trigger immune responses—a phenomenon known as tumor immunogenicity. While some tumors exploit these genomic changes to evade immune detection, others become more immunogenic, increasing their susceptibility to immune surveillance and immunotherapy. read more
Giuseppe Leuzzi's Previous publications
Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens.
Walsh ZH, Shah P, Kothapalli N, Shah SB, Nikolenyi G, Brodtman DZ, Leuzzi G, Rogava M, Mu M, Ho P, Abuzaid S, Vasan N, AlQuraishi M, Milner JD, Ciccia A, Melms JC, Izar B.
Nat Biotechnol. 2025 Mar;43(3):384-395. doi:10.1038/s41587-024-02235-x. PMID: 38783148
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap.
Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu X, Costa JA, Pezet MG, Chou J, Chen C, Paiva M, Snoeck HW, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT.
Nat Biotechnol. 2024 Oct 7. doi:10.1038/s41587-024-02386-x. PMID: 39375448
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.
Leuzzi G, Vasciaveo A, Taglialatela A, Chen X, Firestone TM, et al.
Cell. 2024 Feb 15;187(4):861-881.e32. doi:10.1016/j.cell.2024.01.008
The DNA Damage Response and Inflammation in Cancer.
Klapp V, Álvarez-Abril B, Leuzzi G, Kroemer G, Ciccia A, Galluzzi L.
Cancer Discov. 2023 Jul 7;13(7):1521-1545. doi:10.1158/2159-8290.CD-22-1220
Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.
Conte MI, Poli MC, Taglialatela A, Leuzzi G, et al.
JCI Insight. 2022 Nov 8;7(21):e154948. doi:10.1172/jci.insight.154948