IFOM

Publications 2025

last update May 2026
  1. Adaptive plasticity in targeted therapy.
    Vito Amodio; Giorgio Patelli; Alberto Bardelli
    (2025) Cancer cell 2026 Jan 12 - Epub 2025 Dec 31 10.1016/j.ccell.2025.12.007 [41478275]

  2. p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism.
    Kathrin Laue; Sabina Pozzi; Johanna Zerbib; Rebecca Bertolio; Yonatan Eliezer; Yael Cohen-Sharir; Tom Winkler; Manuel Caputo; Alessia A Ricci; Lital Adler; Rami Khoury; Giuseppe Longobardi; Rachel Slutsky; Alicia I Leikin-Frenkel; Shai Ovadia; Katharina Lange; Alessandra Rustighi; Silvano Piazza; Andrea Sacconi; Rayna Y Magesh; Faith N Keller; Jean Berthelet; Alexander Schäffer; Ron Saad; Sahar Israeli Dangoor; Karolina Szczepanowska; Iris Barshack; Yang Liao; Sergey Malitsky; Alexander Brandis; Thomas Broggini; Marcus Czabanka; Wei Shi; Delphine Merino; Emma V Watson; Giovanni Blandino; Ayelet Erez; Ruth Ashery-Padan; Hind Medyouf; Luca Bertero; Giannino Del Sal; Ronit Satchi-Fainaro; Uri Ben-David
    (2025) Nature genetics 2026 Jan - Epub 2025 Dec 29 10.1038/s41588-025-02446-1 [41461910]

  3. The Janus framework of the integrated stress response: from homeostasis to maladaptation.
    Dogus M Altintas; Marina Cerqua; Paolo M Comoglio; Cédric Chaveroux
    (2025) Life science alliance 2026 Mar - Epub 2025 Dec 29 10.26508/lsa.202503523 [41461564]

  4. Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program.
    Daniele Vignoli; Marco Albertini; Carlos Chiatti; Gianluca Aimaretti; Giovanna Boccuzzo; Vanna Boffo; Agar Brugiavini; Filippo Cavallo; Simone Cenci; Antonio Cherubini; Febo Cincotti; Fabrizio d'Adda di Fagagna; Carlo Ferrarese; Vincenzo Galasso; Elisabetta Galeotti; Andrea Graziani; Guido Iaccarino; Fabrizia Lattanzio; Claudio Lucifora; Mario Mezzanzanica; Giuseppe Passarino; Anna Paterno; Sabrina Prati; Raffaella I Rumiati; Marco Sandri; Cecilia Tomassini; Alexandra Torbica; Andrea Ungar; Alessandra Petrucci
    (2025) The journals of gerontology. Series B, Psychological sciences and social sciences 2025 Dec 01 10.1093/geronb/gbaf219 [41442765]

  5. Improving our understanding of the biology of aging: findings from the Age-It Research Program.
    Fabrizio Chiti; Fiorenzo Conti; Daniela Corda; Francesco Giorgino; Andrea Graziani; Giuseppe Passarino; Marco Sandri; Fabrizio d'Adda di Fagagna
    (2025) The journals of gerontology. Series B, Psychological sciences and social sciences 2025 Dec 01 10.1093/geronb/gbaf197 [41442755]

  6. De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems.
    Hind Abdo; Leonardo Barzaghi; Yuan Shen; Edoardo Bellini; Emanuele Martini; Serena Magni; Sara Barozzi; Fabrizio Orsenigo; Dario Parazzoli; Galina V Beznoussenko; Jasmin Di Franco; Fabian Krautgasser; Jasmin Kaivola; Mario Cinquanta; Alessandro Lazzarin; Sara Sigismund; Johanna Ivaska; Roberto Cerbino; Giorgio Scita
    (2025) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec 23 10.1002/advs.202508648 [41431893]

  7. Single cell RNAseq signatures refined with combiroc enhance identification of NK cells in blood and solid tissues.
    Ivan Ferrari; Saveria Mazzara; Andrea Gobbini; Noemi Di Marzo; Mariacristina Crosti; Sergio Abrignani; Renata Grifantini; Mauro Bombaci; Riccardo L Rossi
    (2025) Scientific reports 2025 Dec 18 10.1038/s41598-025-29876-5 [41413116]

  8. Brillouin Microscopy of Breast tumor Spheroids On-a-Chip: Mechanical and Transcriptional Responses to Microfluidic-Induced Rapid Deformations.
    Mona Makkieh; Alessandra Anna Passeri; Davide Lazzari; Stefano Marchesi; Andrea Disanza; Rafal Khaled Ahmad Salem; Francesco Bonacci; Camillo Mazzella; Emanuele Martini; Mattia Tonani; Leonardo Donati; Edoardo Bellini; Hind Abdo; Judith Pineau; Serena Magni; Fabrizio Orsenigo; Matthieu Piel; Daniele Fioretto; Sabata Martino; Maurizio Mattarelli; Giorgio Scita; Brenda J Green; Silvia Caponi
    (2025) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan - Epub 2025 Dec 16 10.1002/advs.202513153 [41399996]

  9. An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells.
    Beatrice Anfuso; Suresh Velnati; Davide Selvestrel; Clara Garlant; Elisa Ferracci; Gabriele Baj; Pietro Parisse; Diletta Overi; Rebecca Bertolio; Roberta Bulla; Aurelio Sonzogni; Matteo Bramuzzo; Loredana Casalis; Nicholas Cocomello; Francesco Baratta; Maria Del Ben; Pablo Giraudi; Claudio Tiribelli; Natalia Rosso; Manuela Mastronardi; Paola Tarchi; Maurizio Pinamonti; Fabrizio Zanconati; Nicolò de Manzini; Eugenio Gaudio; Silvia Palmisano; Deborah Bonazza; Giannino Del Sal; Guido Carpino; Fulvio Chiacchiera; Giovanni Sorrentino
    (2025) Cell reports 2025 Dec 23 10.1016/j.celrep.2025.116681 [41389211]

  10. A human CAGinSTEM? platform for decoding HTT repeats' somatic instability links CAG interruption to HD pathology in neurons.
    Martina Zobel; Gianluca Damaggio; Maria Lidia Mignogna; Dario Besusso; Davide Scalzo; Andrea Cossu; Camilla Trovesi; Mariacristina Crosti; Francesco Cortina; Ilaria Campus; Giulio Formenti; Saveria Mazzara; Francesco Gregoretti; Laura Antonelli; Gennaro Oliva; Chiara Zuccato; Vincenza Colonna; Paola Conforti; Matteo Cereda; Riccardo Lorenzo Rossi; Simone Maestri; Andrea Scolz; Raffale Iennaco; Elena Cattaneo
    (2025) Cell reports 2025 Dec 23 10.1016/j.celrep.2025.116685 [41389205]

  11. High-Throughput Molecular Characterization of the Microbiome in Breast Implant-Associated Anaplastic Large Cell Lymphoma and Peri-Implant Benign Seromas.
    Evelina Rogges; Giorgio Bertolazzi; Davide Vacca; Marina Borro; Gianluca Lopez; Maurizio Simmaco; Anna Scattone; Guido Firmani; Michail Sorotos; Fabio Santanelli di Pompeo; Niccolò Noccioli; Emanuele Savino; Andrea Vecchione; Arianna Di Napoli
    (2025) Cancers 2025 Nov 29 10.3390/cancers17233839 [41375040]

  12. Fasting boosts breast cancer therapy efficacy via glucocorticoid activation.
    Nuno Padrão; Tesa M Severson; Sebastian Gregoricchio; Ana Guijarro; Catrin Lutz; Daniel Taranto; Stefan Hutten; Francesca Ligorio; Angelica Persia; Merel Roest; Joyce Sanders; Ji-Ying Song; Sara Pires-Oliveira; Maria Donaldson Collier; Hugo Horlings; Livia Pisciotta; Filippo de Braud; Claudio Vernieri; Leila Akkari; Jos Jonkers; Alessio Nencioni; Irene Caffa; Wilbert Zwart
    (2025) Nature 2026 Jan - Epub 2025 Dec 10 10.1038/s41586-025-09869-0 [41372410]

  13. DROSHA, DICER, and damage-induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break.
    Francesca Esposito; Ilaria Capozzo; Adelaide Riccardi; Ubaldo Gioia; Stefania Modafferi; Letizia Manfredi; Alessio Colantoni; Sara Tavella; Matteo Cabrini; Fabio Iannelli; Alessia di Lillo; Fabrizio d'Adda di Fagagna; Sofia Francia
    (2025) Cell reports 2025 Dec 23 10.1016/j.celrep.2025.116605 [41348540]

  14. Partial Alopecia Area Retains Bulge Hair Follicle Progenitor Cells in Indian Androgenetic Alopecia Patients.
    Akshay Hegde; Dyuti Saha; Savitha Somaiah; Colin Jamora
    (2025) International journal of trichology 2025 10.4103/ijt.ijt_27_24 [41346559]

  15. miR-382-5p and miR-34a in migraine: Expression in monocytes and a post-hoc exploratory comparison with expression in peripheral blood mononuclear cells.
    Rosaria Greco; Federico Bighiani; Chiara Demartini; Annamaria Zanaboni; Miriam Francavilla; Sara Facchetti; Daisy Sproviero; Gloria Vaghi; Marta Allena; Daniele Martinelli; Michele Corrado; Elena Guaschino; Natascia Ghiotto; Sara Bottiroli; Francescantonio Cammarota; Alessandro Antoniazzi; Valentina Grillo; Grazia Sances; Cristina Tassorelli; Roberto De Icco
    (2025) Cephalalgia : an international journal of headache 2025 Dec 10.1177/03331024251386769 [41342643]

  16. Epigenetic drivers of chromosomal instability.
    Ilio Vitale; Matteo Cereda; Lorenzo Galluzzi
    (2025) Trends in cancer 2025 Dec 02 10.1016/j.trecan.2025.11.010 [41339187]

  17. Efficacy and safety of atezolizumab plus bevacizumab in MSI-like metastatic colorectal cancer: a multicenter, single-arm, phase II, open-label clinical trial.
    E Elez; S Siena; A Sartore-Bianchi; J Ros; F Ciardello; E Martinelli; N Steeghs; S Huijberts; A Cervantes; S Roselló; S Tejpar; B Wilmsen; R Salazar; C Santos; G de Schaetzen; S Muñoz; R Bernards; V Moreno; E García-Galera; R Alemany; A Gros; A Bardelli; S Arena; A Piris; E Chavarría; R Dienstmann; J Tabernero
    (2025) ESMO open 2025 Dec 10.1016/j.esmoop.2025.105892 [41337858]

  18. A subset of MMR-proficient colon cancers responds to neoadjuvant immunotherapy.
    Eleonora Piumatti; Giovanni Germano; Pietro Paolo Vitiello; Alberto Bardelli
    (2025) Molecular oncology 2025 Nov 30 10.1002/1878-0261.70178 [41321030]

  19. Localized Wnt-signaling promotes asymmetric NuMA?-dependent oriented divisions and unequal apportioning of mitochondria.
    Susanna Eli; Greta Rauso; Paola Ghezzi; James L A Szczerkowski; Michela Bruzzi; Francesca Rizzelli; Fabiola Iommazzo; Alessia Loffreda; Francesco Castagna; Federico Donà; Chiara Gaddoni; Ambra Dondi; Mattia Marenda; Simona Rodighiero; Pierre Tournier; Zeno Lavagnino; Dario Parazzoli; Nils C Gauthier; Simone Tamburri; Diego Pasini; Shukry James Habib; Marina Mapelli
    (2025) Nature communications 2025 Nov 27 10.1038/s41467-025-65775-z [41310344]

  20. Total neoadjuvant therapy followed by non-operative management or surgery in stage II-III rectal cancer (NO-CUT): a multicentre, single-arm, phase 2 trial.
    Alessio Amatu; Giorgio Patelli; Maria Giulia Zampino; Francesca Bergamo; Stefania Mosconi; Federica Tosi; Davide Ciardiello; Sara Lonardi; Giorgia Negrini; Daniela Sibio; Marianna Alessandra Gerardi; Sara Galuppo; Francesco Romeo Filippone; Pietro Carnevali; Simona Borin; Pierluigi Pilati; Elia Poiasina; Erica Bonazzina; Lorenzo Gervaso; Enzo Mammano; Francesco Bracco; Luca Bergamaschi; Gaya Spolverato; Matteo Origi; Uberto Fumagalli Romario; Gianluca Mauri; Nicola Fazio; Edoardo Forti; Giuseppe De Roberto; Chiara Cristofori; Cesare Burti; Luigi Asmundo; Luigi Funicelli; Gaetano Ramondo; Pietro Andrea Bonaffini; Sara Mariano; Luca Lazzari; Silvia Ghezzi; Claudio Isella; Daniela Cantarella; Maria Costanza Aquilano; Luca Bottiglieri; Emanuela Bonoldi; Massimiliano Mutignani; Valter Torri; Enzo Medico; Alberto Bardelli; Silvia Marsoni; Angelo Vanzulli; Mauro Filippo Palazzi; Giovanni Carlo Ferrari; Katia Bencardino; Andrea Sartore-Bianchi; Salvatore Siena
    (2025) The Lancet. Oncology 2025 Dec 10.1016/S1470-2045(25)00542-X [41308677]

  21. Author Correction: A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression.
    Daisy Sproviero; César Payán-Gómez; Chiara Milanese; Sander Barnhoorn; Shixiang Sun; Akos Gyenis; Domenico Delia; Tammaryn Lashley; Jan H J Hoeijmakers; Jan Vijg; Pier G Mastroberardino
    (2025) Nature aging 10.1038/s43587-025-01037-3 [41258491]

  22. IgAim?: cell surface Ig-aimed immune memory erasers for the therapy of autoimmune diseases and B leukemia.
    Hiroshi Arakawa
    (2025) NAR molecular medicine 2025 Apr 10.1093/narmme/ugaf016 [41255710]

  23. Sentinel Node Biopsy Alone Versus Sentinel Node Biopsy Plus Axillary Dissection in cT2 cN0/1 Breast Cancer After Neoadjuvant Chemotherapy: 15-Year Results of a Prospective Interventional Study.
    Gabriele Martelli; Francesco Barretta; Carlo Muzi; Chiara Listorti; Federica Pilotta; Ilaria Maugeri; Chiara Osio; Deborah Bonfili; Claudio Vernieri; Giulia Bianchi; Giancarlo Pruneri; Secondo Folli; Gianfranco Scaperrotta; Paolo Baili; Rosalba Miceli; Cristina Ferraris
    (2025) Annals of surgical oncology 2025 Nov 18 10.1245/s10434-025-18673-z [41251914]

  24. Targeting HER2 in Metastatic Colorectal Cancer: Current Therapies, Biomarker Refinement, and Emerging Strategies.
    Caterina Vaghi; Federica Tosi; Gianluca Mauri; Erica Bonazzina; Alessio Amatu; Katia Bencardino; Daniele Piscazzi; Laura Roazzi; Federica Villa; Michelangelo Maggi; Letizia Monti; Anna Bombelli; Giovanna Marrapese; Silvia Ghezzi; Giorgio Patelli; Javier Ros; Elena Elez; Andrea Sartore-Bianchi; Salvatore Siena
    (2025) Drugs 2026 Jan - Epub 2025 Nov 17 10.1007/s40265-025-02253-2 [41247589]

  25. Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer.
    Amandine Billaud; Gisella Figlioli; Clémence Mooser; Irene Casamassima; Violette Azzoni; Jahnavi Srivatsa; Mara Colombo; Laura Caleca; Thomas U Ahearn; Irene L Andrulis; Antonis C Antoniou; Matthias W Beckmann; Sabine Behrens; Marina Bermisheva; Natalia V Bogdanova; Manjeet K Bolla; Bernardo Bonanni; Thomas Brüning; Nicola J Camp; Archie Campbell; Jose E Castelao; Melissa H Cessna; Jenny Chang-Claude; NBCS Collaborators; Kamila Czene; Joe Dennis; Peter Devilee; Thilo Dörk; Alison M Dunning; Mikael Eriksson; D Gareth Evans; Peter A Fasching; Jonine D Figueroa; Marike Gabrielson; Manuela Gago-Dominguez; Anna González-Neira; Pascal Guénel; Andreas Hadjisavvas; Eric Hahnen; Ute Hamann; Peter Hillemanns; Antoinette Hollestelle; Maartje J Hooning; Reiner Hoppe; Anthony Howell; kConFab Investigators; Anna Jakubowska; Vessela N Kristensen; Jan Lubi?ski; Michael Lush; Siranoush Manoukian; Dimitrios Mavroudis; Roger L Milne; Anna Marie Mulligan; William G Newman; Nadia Obi; Mihalis I Panayiotidis; Guillermo Pita; Muhammad U Rashid; Valerie Rhenius; Emmanouil Saloustros; Elinor J Sawyer; Rita K Schmutzler; Mitul Shah; Melissa C Southey; Amanda B Spurdle; Ian Tomlinson; Thérèse Truong; Qin Wang; Camilla Wendt; Paul L Auer; Nicholas J Boddicker; Clara Bodelon; Elizabeth S Burnside; Fei Chen; Fergus J Couch; Susan M Domchek; Heather A Eliassen; Christopher Haiman; James M Hodge; Chunling Hu; Hongyan Huang; Sara Lindstrom; Maria Elena Martinez; Katherine L Nathanson; Susan L Neuhausen; Katie M O'Brien; Janet E Olson; Julie R Palmer; Alpa V Patel; Kathryn J Ruddy; Dale P Sandler; Lauren R Teras; Clarice R Weinberg; Jeffrey N Weitzel; Stacey J Winham; Siddhartha Yadav; Song Yao; Gary Zirpoli; Marketa Janatova; Zdenek Kleibl; Petra Kleiblova; Jana Soukupova; CZECANCA consortium; Qihong Zhao; Lisa Devereux; Paul A James; Ian G Campbell; Tu Nguyen-Dumont; James G Dowty; Nadine Andrieu; Fabienne Lesueur; Dominique Stoppa-Lyonnet; GENESIS; Miguel de la Hoya; Paolo Radice; Claus Storgaard Sørensen; Paolo Peterlongo
    (2025) Breast (Edinburgh, Scotland) 2025 Oct 30 10.1016/j.breast.2025.104619 [41223770]

  26. Ubiquitin choreography in nasopharyngeal carcinoma: USP18 scaffolds radioresistance.
    Francesco Napoletano; Rebecca Bertolio; Giannino Del Sal
    (2025) Cell death and differentiation 2025 Nov 11 10.1038/s41418-025-01616-2 [41219492]

  27. The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells.
    Angela Lauriola; Juliana Haydeé Enriqué Steinberg; Motoharu Sarubo; Elena Maspero; Fabiana Alejandra Rossi; Yasuhiro Mouri; Marco Pedretti; Mohsen Hajisadeghian; Vincenzo Taibi; Andrea Vettori; Nicola Vitulo; Michael Assfalg; Mariapina D'Onofrio; Mario Rossi; Akihiro Yasue; Alessandra Astegno; Simona Polo; Spartaco Santi; Yasusei Kudo; Daniele Guardavaccaro
    (2025) Molecular cell 2025 Nov 20 10.1016/j.molcel.2025.10.005 [41167191]

  28. Clinical Actionability of Genes in Gastrointestinal Tumors.
    Nadia Saoudi Gonzalez; Giorgio Patelli; Giovanni Crisafulli
    (2025) Genes 2025 Sep 25 10.3390/genes16101130 [41153346]

  29. Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance.
    Marianna Ponzo; Lorenzo Drufuca; Chiara Buracchi; Marco M Sindoni; Silvia Nucera; Cristina Bugarin; Ramona Bason; Grazisa Rossetti; Raoul Bonnal; Cristian Meli; Benedetta Rambaldi; Federico Lussana; Silvia Ferrari; Alex Moretti; Giuseppe Dastoli; Giulia Risca; Christian Pellegrino; Markus G Manz; Stefania Galimberti; Alessandro Rambaldi; Giuseppe Gaipa; Andrea Biondi; Massimiliano Pagani; Chiara F Magnani
    (2025) Journal for immunotherapy of cancer 2025 Oct 23 10.1136/jitc-2025-011768 [41135951]

  30. Chromatin remodeling restrains oncogenic functions in prostate cancer.
    Valentina Rosti; Giovanni Lembo; Cristiano Petrini; Francesca Gorini; Roberto Quadri; Chiara Cordiglieri; Margherita Mutarelli; Elisa Salviato; Elisabetta Casari; Emanuele Di Patrizio Soldateschi; Emanuele Montanari; Giancarlo Albo; Francesco Ripa; Alessandra Fasciani; Mariacristina Crosti; Elisa De Lorenzis; Marco Maggioni; Valentina Vaira; Maria Vivo; Francesco Ferrari; Chiara Lanzuolo
    (2025) Nature communications 2025 Oct 16 10.1038/s41467-025-64213-4 [41102163]

  31. Efficacy and safety of systemic therapies following progression on CDK4/6 inhibitors in patients with HR+/HER2- metastatic breast cancer: a systematic review and network meta-analysis.
    Roberto Buonaiuto; Mario Fordellone; Aldo Caltavituro; Maria Letizia Cataldo; Carmen Criscitiello; Maria Vittoria Dieci; Matteo Lambertini; Andrea Botticelli; Mario Giuliano; Antonio Giordano; Federica Mangiacotti; Angela Grieco; Alessandra Longobardi; Roberta Caputo; Martina Pagliuca; Claudio Vernieri; Luca Malorni; Lorenzo Gerratana; Grazia Arpino; Paolo Chiodini; Michelino De Laurentiis; Carmine De Angelis
    (2025) EClinicalMedicine? 2025 Nov 10.1016/j.eclinm.2025.103535 [41079023]

  32. Acetylation of lysine 49 on Ctnnb1 drives naïve pluripotency in murine stem cells by modulating Nanog function.
    Toshiyuki Takehara; Mahito Nakanishi; Raku Son; Hirofumi Suemori; Yasuhiro Murakawa; Takeshi Teramura
    (2025) PNAS nexus 2025 Oct 10.1093/pnasnexus/pgaf297 [41064241]

  33. Zebrafish Xenograft Model for Predicting Cisplatin Efficacy in Muscle-Invasive Bladder Cancer.
    Yusuke Sugino; Xin Bao; Sho Sekito; Shiori Miyachi; Takumi Kageyama; Takeshi Sasaki; Kouhei Nishikawa; Toshio Tanaka; Manabu Kato; Yasuhito Shimada; Keishi Takano; Raku Son; Liqing Zang; Kenji Nakayama; Masatoshi Watanabe; Yasuhiro Murakawa; Takahiro Inoue
    (2025) Cancer science 2025 Dec 10.1111/cas.70217 [41059675]

  34. Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling.
    Giada Vanni; Anna Citron; Ambela Suli; Paolo Contessotto; Robin Caire; Alessandro Gandin; Giovanna Mantovan; Francesca Zanconato; Giovanna Brusatin; Michele Di Palma; Elisa Peirano; Lisa Sofia Pozzer; Carlo Albanese; Roberto A Steiner; Michelangelo Cordenonsi; Tito Panciera; Stefano Piccolo
    (2025) Nature cell biology 2025 Oct 10.1038/s41556-025-01773-z [41034521]

  35. Periodic fasting induced reconstitution of metabolic flexibility improves albuminuria in patients with type 2 diabetes.
    Alba Sulaj 1, Phong B H Nguyen 2, Gernot Poschet 3, Elisabeth Kliemank 4, Thomas Fleming 4, Lea Henke 4, Wiebke Neibig 4, Stefan Kopf 5, Rüdiger Hell 3, Valter D Longo 6, Stephan Herzig 7, Peter P Nawroth 8, Michael P Menden 9, Julia Szendroedi 8
    (2025) Molecular metabolism 2025 Dec 10.1016/j.molmet.2025.102257 [41005725]

  36. Mismatch Repair as a Dynamic and Clinically Actionable Vulnerability in Cancer.
    Eleonora Piumatti; Pietro Paolo Vitiello; Vito Amodio; Alberto Bardelli; Giovanni Germano
    (2025) Cancer research 2025 Nov 14 10.1158/0008-5472.CAN-25-2255 [40991396]

  37. Author Correction: Fasting mimicking diet cycles versus a Mediterranean diet and cardiometabolic risk in overweight and obese hypertensive subjects: a randomized clinical trial.
    Amrendra Mishra; Maura Fanti; Xinzhou Ge; Don Vaughn; Sebastian Brandhorst; Min Wei; Kurt M Hong; Matteo Pellegrini; Hanno Pijl; Mark C Houston; Valter D Longo
    (2025) npj metabolic health and disease 2025 Sep 23 10.1038/s44324-025-00084-z [40987812]

  38. Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression.
    Marta Milan; Valeria Runfola; Manthan Patel; Lucia Falbo; Roberta Noberini; Chiara Soriani; Simona Rodighiero; Tiziana Bonaldi; Vincenzo Costanzo; Madapura M Pradeepa; Paola Scaffidi
    (2025) Nucleic acids research 2025 Sep 23 10.1093/nar/gkaf916 [40985775]

  39. Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer's disease.
    Sara Sepe; Federica Rey; Alexandra Mancheno-Ferris; Alessandra Bigi; Giulia Fani; Devid Damiani; Matteo Cabrini; Eugenia Marinelli; Julio Aguado; Liliana Contu; Alessia di Lillo; Sara Boggio; Sara Tavella; Ilaria Rosso; Stefano Gustincich; Fabrizio Chiti; Fabrizio d'Adda di Fagagna
    (2025) The EMBO journal 2025 Nov 10.1038/s44318-025-00521-1 [40976786]

  40. KRAS G12C Inhibition in Solid Tumors: Biological Breakthroughs, Clinical Evidence, and Open Challenges.
    Pietro Paolo Vitiello; Anna Amela Valsecchi; Eleonora Duregon; Paola Francia Di Celle; Paola Cassoni; Mauro Papotti; Alberto Bardelli; Massimo Di Maio
    (2025) Cancers 2025 Aug 27 10.3390/cancers17172803 [40940900]

  41. Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
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  42. A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression.
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  45. Potential Involvement of Myostatin in Smooth Muscle Differentiation in Pleomorphic Leiomyosarcoma.
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  46. Exploring the Relationship Between Insulin Resistance, Liver Health, and Restrictive Lung Diseases in Type 2 Diabetes.
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  48. Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models.
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  49. Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells.
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  53. Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis.
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  54. HGF Overexpression in Mesenchymal Stromal Cell-Based Cell Sheets Enhances Autophagy-Dependent Cytoprotection and Proliferation to Guard the Epicardial Mesothelium.
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  55. Structure of the Secretory Compartments in Goblet Cells in the Colon and Small Intestine.
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  57. Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor-like family member 2.
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  58. Correction: Preoperative ctDNA retains prognostic relevance beyond postoperative assessment in stage II-III colon cancer.
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  59. Patient-Derived Explants of Osteoarthritic Synovium as Ex Vivo Model for Preclinical Research.
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  60. RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics.
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  61. Gene expression profiling in a retrospective real-world cohort of breast cancer brain metastases and paired primary tumors identifies biological changes with potential therapeutic implications.
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  62. The 50-nm Free Vesicles Visible in Saccharomyces cerevisiae Are Not COPII-Dependent.
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  63. Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone.
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  64. Sirtuins and their role in ovarian aging-related fibrosis predisposing to ovarian cancer.
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  65. TRF1 relies on fork reversal to prevent fragility at human telomeres.
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  66. Biomarkers of psychological stress are associated with increased susceptibility to the development of breast and prostate cancer in BRCA1/2 mutation carriers.
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  67. Preoperative ctDNA retains prognostic relevance beyond postoperative assessment in stage II-III colon cancer.
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  71. Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility.
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  76. Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency.
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  77. Correction: CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer.
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  78. DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.
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  79. Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4.
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  126. At the nucleus of cancer: how the nuclear envelope controls tumor progression.
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