Marco Foiani Lab

Marco Foiani

A molecular biologist by training, Marco Foiani heads the genome integrity research lab at IFOM. Marco obtained his Ph.D is molecular and cell biology in 1988 from University of Milan under Prof. Paolo Plevani. After a short stint as a post-doctoral fellow in the lab of Prof. Plevani and G. Lucchini, in 1989, Marco moved to the lab of Dr. Alan Hinnebush at NIH-NICHD, Bethesda in the USA for his post-doctoral studies and remained there till 1991. read more

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Genome Integrity

Broad focus of our research is on cellular pathways which maintain genomic integrity in response to various stressors ranging from intrinsic topological stress due to conflicts between replication and transcription or extrinsic mechanical stress exerted by cytoskeletal or extracellular matrix forces. read more

Laboratory location: Milan, Italy

Recent publications

Martin Kosar, Michele Giannattasio, Daniele Piccini, Apolinar Maya-Mendoza, Francisco García-Benítez, Jirina Bartkova, Sonia I. Barroso, Hélène Gaillard, Umberto Restuccia, Massimiliano Garre, Eleonora Verga, Emanuele Martini, Miguel Andújar Sánchez, Scott Maynard, Zdenek Hodny, Amit Kumar, Angela Bachi, Andres Aguilera, Jiri Bartek, Marco Foiani.
Human nucleoporin Tpr coordinates mRNA processing to protect cells from RNA-mediated replication stress.
Nat Commun. 2021, in press.

Arta Ajazi, Christopher Bruhn, Ghadeer Shubassi, Chiara Lucca, Angela Cattaneo, Angela Bachi, Nicola Manfrini, Stefano Biffo, Emanuele Martini, Saverio Minucci, Claudio Vernieri, Marco Foiani.
Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis.
Developmental Cell, 2021, in press.

Kidiyoor GR, Li Q, Bastianello G, Bruhn C, Giovannetti I, Mohamood A, Beznoussenko GV, Mironov A, Raab M, Piel M, Restuccia U, Matafora V, Bachi A, Barozzi S, Parazzoli D, Frittoli E, Palamidessi A, Panciera T, Piccolo S, Scita G, Maiuri P, Havas KM, Zhou ZW, Kumar A, Bartek J, Wang ZQ, Foiani M.
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration,
Nat Commun. 2020 Sep 24;11(1):4828. doi: 10.1038/s41467-020-18580-9.PMID: 32973141.

Bruhn C, Ajazi A, Ferrari E, Lanz MC, Batrin R, Choudhary R, Walvekar A, Laxman S, Longhese MP, Fabre E, Smolka MB, Foiani M.
The Rad53 ^CHK1/CHK2-Spt21 ^NPAT and Tel1 ^ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing,
Nat Commun. 2020 Aug 19;11(1):4154. doi: 10.1038/s41467-020-17961-4., PMID: 32814778.

Achar YJ, Adhil M, Choudhary R, Gilbert N, Foiani M.
Negative supercoil at gene boundaries modulates gene topology.
Nature. 2020 Jan;577(7792):701-705. doi: 10.1038/s41586-020-1934-4. Epub 2020 Jan 22.