IFOM Dana Branzei Lab

Dana Branzei Lab

Dana Branzei

Molecular biologist Dana Branzei researches mechanisms of DNA repair and replication stress tolerance that operate in eukaryotic cells, and how they impact on chromosome structure. At a young age Dana, as well as members of the scientific community, discovered her talent for science. read more

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DNA Repair

Accurate chromosomal DNA replication is of fundamental importance for cellular function, genome integrity and development. In response to replication perturbations, DNA damage response (DDR) and DNA damage tolerance (DDT) pathways become activated and are crucial for detection and tolerance of lesions, as well as for replication completion and chromosome structural integrity. read more

Laboratory location: Milan, Italy

Recent publications

  • Ivan Psakhye, Federica Castellucci, Dana Branzei* (2019).
    SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation.
    Mol Cell pii: S1097-2765(19)30619-7. doi: 10.1016/j.molcel.2019.08.003.
  • Michele Giannattasio, Dana Branzei* (2019).
    DNA Replication Through Strand Displacement During Lagging Strand DNA Synthesis in Saccharomyces cerevisiae.
    Genes pii: E167. doi: 10.3390/genes10020167.
  • Takuya Abe, Ryotaro Kawasumi, Michele Giannattasio, Sabrina Dusi, Yui Yoshimoto, Keiji Miyata, Koyuki Umemura, Kouji Hirota, and Dana Branzei* (2018)
    AND-1 fork protection function prevents fork resection and is essential for proliferation.
    Nat Commun 9: 3091. doi: 10.1038/s41467-018-05586-7.
  • Takuya Abe, Masato Ooka, Ryotaro Kawasumi, Keiji Miyata, Minoru Takata, Kouji Hirota, and Dana Branzei* (2018).
    Warsaw Breakage Syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.
    Proc Natl Acad Sci pii: 201803110. doi: 10.1073/pnas.1803110115.
  • Ryotaro Kawasumi, Takuya Abe*, Hiroshi Arakawa, Massimiliano Garre, Kouji Hirota, and Dana Branzei* (2017).
    ESCO1/2 roles in chromosome structure and interphase chromatin organization.
    Genes Dev, doi: 10.1101/gad.306084.117.
  • Dana Branzei* and Barnabas Szakal (2017).
    Building up and breaking down: mechanisms controlling recombination during replication.
    Crit Rev Biochem Mol Biol 52: 381-394.
  • Takuya Abe, Ryotaro Kawasumi, Hiroshi Arakawa, Tetsuya Hori, Katsuhiko Shirahige, Ana Losada, Tatsuo Fukagawa, and Dana Branzei* (2016).
    Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion.
    Oncotarget, doi: 10.18632/oncotarget.11982.
  • Demis Menolfi, Axel Delamarre, Armelle Lengronne, Philippe Pasero and Dana Branzei* (2015).
    Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance.
    Mol Cell 60: 835-846. (see also comments on this article in PMID: 2668759, PMID:26694861)
  • Madhusoodanan Urulangodi, Marek Sebesta, Demis Menolfi, Barnabas Szakal, Julie Sollier, Alexandra Sisakova, Lumir Krejci, and Dana Branzei* (2015).
    Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication.
    Genes Dev 29 (19). (see also comments on this article in PMID: 26587752).
  • Marco Fumasoni, Katharina Zwicky, Fabio Vanoli, Massimo Lopes and Dana Branzei* (2015).
    Error-free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polalpha/Primase/Ctf4 Complex.
    Mol Cell 57: 812-823.
  • * indicates the corresponding author

Group members

Staff Scientist
Szakal Barnabas
Dusi Sabrina
Post doc
Joseph Chinnu Rose
Kawasumi Ryotaro
Nunomiya Aki
Psakhye Ivan
Villa Matteo
PhD students
Dolce Valeria
Jegadesan Nanda Kumar
Morea Alessandro
Reyes Clarisse Teresa Anne
Former Lab members
Demis Menolfi (Master student, PhD student, postdoc)
Marco Fumasoni (Master student, PhD student, postdoc)
Federica Castellucci (PhD student, postdoc)
Saho Era (PhD student)
Takuya Abe (postdoc)
Madhusoodanan Urulangodi (postdoc)
Victor Gonzalez-Huici (postdoc)
Marek Sebesta (postdoc)
Fabio Vanoli (postdoc)
Julie Sollier (postdoc)
Eerappa Rajakumara (postdoc)
Livia Provitera (postdoc)
Teresa Anne Clarisse Reyes (Master student)
Beatrice Toia (Master student)
Alexandra Mayer (postdoc)
Francesco Rossi (PhD student, postdoc)

(update: Mar 2021)

IFOM Review

Seeing is believing: catching template-switching in the act
Commentary on Dana Branzei's paper published on Nature Structural & Molecular Biology, by Michael Lichten (2015)
complete review

Press releases


In the press

Quelli che decidono di restare in Italia

Il Corriere della Sera | G.Caprara, A. De Gregorio, V. Santarpia

Unravelling the secrets of DNA repair


DNA lifting
Marie Claire

2010.03.01 | Enrica Caretta

La poetessa del SUMO figlia del mondo


Ricera, italiani primi ma in fuga
Corriere della Sera

2009.10.08 | Gabriella Jacomella

view all press review