IFOM Yasuhiro Murakawa Lab

Yasuhiro Murakawa Lab

Yasuhiro Murakawa

Yasuhiro Murakawa

Systems biologist Yasuhiro Murakawa directs the RIKEN-IFOM Joint Laboratory for Cancer Genomics.
He graduated from Kyoto University School of Medicine in 2008. While he was a medical student, he studied DNA repair in the Shunichi Takeda lab in the department of radiation genetics.

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Cancer Genomics

Our lab uses the computational and experimental approaches to investigate new functional elements encoded in the human genome that function in human health and cancer. To gain fundamental insight into cancer development and maintenance, we decipher the cis-regulatory code that governs the transcriptional landscapes of malignancies.

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Laboratory location: Milan, Italy

Last publications

  • Hirabayashi S., Bhagat S., Matsuki Y., Takegami Y., Uehata T., Kanemaru A., Itoh M., Shirakawa K., Takaori-Kondo A., Takeuchi O., Carninci P., Katayama S., Hayashizaki Y., Kere J., Kawaji H., Murakawa Y.
    NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements.
    Nature Genetics 51(9):1369-1379 (2019)

  • Hia F., Fan Yang S., Shichino Y., Yoshinaga M., Murakawa Y., Vandenbon A., Fukao A., Fujiwara T., Landthaler M., Natsume T., Adachi S., Iwasaki S., Takeuchi O.
    Codon Optimality Confers GC-Rich-Induced Stability to mRNAs in Humans
    EMBO Reports :e48220. doi: 10.15252/embr.201948220 (2019)

  • Yamazaki H., Shirakawa K., Matsumoto T., Hirabayashi S., .Murakawa Y., Kobayashi M., Sarca AD., Kazuma Y., Matsui H., Maruyama W., Fukuda H., Shirakawa R., Shindo K., Ri M., Iida S., Takaori-Kondo A.
    Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells.
    Scietific Reports 9, 7122 (2019)

Group members

PhD student
Shigeki Hirabayashi
Akiko Oguchi
Satoshi Yoshida
(update: Oct 2019)