IFOM Dana Branzei Lab

Dana Branzei Lab

Dana Branzei

Rumena, biologa molecolare, Dana Branzei dirige presso IFOM il Laboratorio dedicato allo studio dei meccanismi di riparazione del DNA.
Già giovanissima, grazie anche al suo mentore - un medico farmacologo che la accompagna nei primi anni del percorso di formazione - scopre la sua vocazione per la chimica. scopri di più

Contatta il ricercatore

Meccanismi di riparazione del DNA

Ricostruire il processo di riparazione del genoma nel corso della duplicazione delle cellule e, quindi, capire in che modo "si aggiusta" dalle lesioni che si possono verificare durante il processo di copiatura dei filamenti di DNA presenti nel nucleo: questo l'obiettivo del programma di ricerca condotto da Dana Branzei. scopri di più

Sede Laboratorio: Milano, Italia

Pubblicazioni Recenti

  • Ivan Psakhye, Federica Castellucci, Dana Branzei* (2019).
    SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation.
    Mol Cell pii: S1097-2765(19)30619-7. doi: 10.1016/j.molcel.2019.08.003.
  • Michele Giannattasio, Dana Branzei* (2019).
    DNA Replication Through Strand Displacement During Lagging Strand DNA Synthesis in Saccharomyces cerevisiae.
    Genes pii: E167. doi: 10.3390/genes10020167.
  • Takuya Abe, Ryotaro Kawasumi, Michele Giannattasio, Sabrina Dusi, Yui Yoshimoto, Keiji Miyata, Koyuki Umemura, Kouji Hirota, and Dana Branzei* (2018)
    AND-1 fork protection function prevents fork resection and is essential for proliferation.
    Nat Commun 9: 3091. doi: 10.1038/s41467-018-05586-7.
  • Takuya Abe, Masato Ooka, Ryotaro Kawasumi, Keiji Miyata, Minoru Takata, Kouji Hirota, and Dana Branzei* (2018).
    Warsaw Breakage Syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.
    Proc Natl Acad Sci pii: 201803110. doi: 10.1073/pnas.1803110115.
  • Ryotaro Kawasumi, Takuya Abe*, Hiroshi Arakawa, Massimiliano Garre, Kouji Hirota, and Dana Branzei* (2017).
    ESCO1/2 roles in chromosome structure and interphase chromatin organization.
    Genes Dev, doi: 10.1101/gad.306084.117.
  • Dana Branzei* and Barnabas Szakal (2017).
    Building up and breaking down: mechanisms controlling recombination during replication.
    Crit Rev Biochem Mol Biol 52: 381-394.
  • Takuya Abe, Ryotaro Kawasumi, Hiroshi Arakawa, Tetsuya Hori, Katsuhiko Shirahige, Ana Losada, Tatsuo Fukagawa, and Dana Branzei* (2016).
    Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion.
    Oncotarget, doi: 10.18632/oncotarget.11982.
  • Demis Menolfi, Axel Delamarre, Armelle Lengronne, Philippe Pasero and Dana Branzei* (2015).
    Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance.
    Mol Cell 60: 835-846. (see also comments on this article in PMID: 2668759, PMID:26694861)
  • Madhusoodanan Urulangodi, Marek Sebesta, Demis Menolfi, Barnabas Szakal, Julie Sollier, Alexandra Sisakova, Lumir Krejci, and Dana Branzei* (2015).
    Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication.
    Genes Dev 29 (19). (see also comments on this article in PMID: 26587752).
  • Marco Fumasoni, Katharina Zwicky, Fabio Vanoli, Massimo Lopes and Dana Branzei* (2015).
    Error-free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polalpha/Primase/Ctf4 Complex.
    Mol Cell 57: 812-823.
  • * indicates the corresponding author

Membri del gruppo

Staff Scientist
Barnabas Szakal
Lab Technician
Sabrina Dusi
Post doc
Ivan Psakhye
Anja Waizzenegger
Valeria Mastrodonato
Matteo Villa
Aki Nunomiya
PhD students
Ryotaro Kawasumi
Sumedha Agashe
Chinnu Rose Joseph
Nanda Kumar Jegadesan
Valeria Dolce
Teresa Anne Clarisse Reyes
Former Lab members
Demis Menolfi (Master student, PhD student, postdoc)
Marco Fumasoni (Master student, PhD student, postdoc)
Federica Castellucci (PhD student, postdoc)
Saho Era (PhD student)
Takuya Abe (postdoc)
Madhusoodanan Urulangodi (postdoc)
Victor Gonzalez-Huici (postdoc)
Marek Sebesta (postdoc)
Fabio Vanoli (postdoc)
Julie Sollier (postdoc)
Eerappa Rajakumara (postdoc)
Livia Provitera (postdoc)
Teresa Anne Clarisse Reyes (Master student)
Beatrice Toia (Master student)
Alexandra Mayer (postdoc)
Francesco Rossi (PhD student, postdoc)

(aggiornato: Dic 2019)

IFOM Review

Seeing is believing: catching template-switching in the act
Commentary on Dana Branzei's paper published on Nature Structural & Molecular Biology, by Michael Lichten (2015)
complete review

Rassegna Stampa

Quelli che decidono di restare in Italia
2016.02.17

Il Corriere della Sera | G.Caprara, A. De Gregorio, V. Santarpia

Unravelling the secrets of DNA repair
euresearcher.com

2013.01.01 

DNA lifting
Marie Claire

2010.03.01 | Enrica Caretta

Rassegna Stampa del ricercatore