Elisabetta Dejana Lab

Elisabetta Dejana

Elisabetta Dejana, a cell biologist and expert on regulation of vascular system development, directs the New strategies to inhibit tumor angiogenesis research unit at IFOM, which focuses on development of tumor vasculature.
After earning a degree in Biological Sciences from the University of Bologna, she moved to Milan to work at the Mario Negri Institute for Pharmacological Research, where she investigated the mechanisms underlying pathological thrombosis and cardiovascular diseases. read more

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New strategies to inhibit tumor angiogenesis

One of the innovative aspects of anti-cancer therapies concerns the possibility of inhibiting tumor growth by blocking blood supply. The simple idea is that, if starved, the tumor will not grow but, on the contrary, will shrink and become more susceptible to chemotherapy and radiotherapy. Cancer cells induce the formation of their own vascular system by recruiting new vessels from the host. However, the resulting vasculature is structurally and functionally abnormal. read more

Laboratory location: Milan, Italy

Recent publications

Cunha SI, Magnusson PU, Dejana E, Lampugnani MG.
Deregulated TGF-β/BMP Signaling in Vascular Malformations.
Circ Res. 2017 Sep 29;121(8):981-999. doi: 10.1161/CIRCRESAHA.117.309930. Review. PMID:28963191
Erba BG, Gruppi C, Corada M, Pisati F, Rosti V, Bartalucci N, Villeval JL, Vannucchi AM, Barosi G, Balduini A, Dejana E.
Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis.
Am J Pathol. 2017 Aug;187(8):1879-1892. doi: 10.1016/j.ajpath.2017.04.006. PMID: 28728747
Dejana E, Hirschi KK, Simons M.
The molecular basis of endothelial cell plasticity.
Nat Commun. 2017 Feb 9;8:14361. doi: 10.1038/ncomms14361. Review. PMID:28181491

complete list PubMed

Group members - IFOM

Guest Researcher

Maria Grazia Lampugnani

Staff Scientist

Monica Corada
Fabrizio Orsenigo

Post Docs

Monica Giannotta
Francesca Lazzaroni
Matteo Malinverno

PhD Students

Mariaelena Valentino
Nikolaos Kakogiannos
Cecilia Savorani

Technician

Claudio Maderna

Undergraduate students

Ambra Nonni

Temporary Fellow

Agata Scalise

Former lab members

Stefan Liebner (Group Leader at Institute of Neurology, Johann Wolfgang Goethe-University Frankfurt, Germany)
Luigi Maddaluno (ETH, Zurich, Switzerland)
Daniel Nyqvist (Group Leader at Karolinska Insitutet, Stockholm, Sweden)
Andrea Taddei (Cancer Research UK, London)

(update: Oct 2019)