Giuseppe Leuzzi's previous publications
Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens.
Walsh ZH, Shah P, Kothapalli N, Shah SB, Nikolenyi G, Brodtman DZ, Leuzzi G, Rogava M, Mu M, Ho P, Abuzaid S, Vasan N, AlQuraishi M, Milner JD, Ciccia A, Melms JC, Izar B.
Nat Biotechnol. 2025 Mar;43(3):384-395. doi:10.1038/s41587-024-02235-x. PMID: 38783148
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap.
Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu X, Costa JA, Pezet MG, Chou J, Chen C, Paiva M, Snoeck HW, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT.
Nat Biotechnol. 2024 Oct 7. doi:10.1038/s41587-024-02386-x. PMID: 39375448
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.
Leuzzi G, Vasciaveo A, Taglialatela A, Chen X, Firestone TM, et al.
Cell. 2024 Feb 15;187(4):861-881.e32. doi:10.1016/j.cell.2024.01.008
The DNA Damage Response and Inflammation in Cancer.
Klapp V, Álvarez-Abril B, Leuzzi G, Kroemer G, Ciccia A, Galluzzi L.
Cancer Discov. 2023 Jul 7;13(7):1521-1545. doi:10.1158/2159-8290.CD-22-1220
Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.
Conte MI, Poli MC, Taglialatela A, Leuzzi G, et al.
JCI Insight. 2022 Nov 8;7(21):e154948. doi:10.1172/jci.insight.154948
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.
Li Y, Goldberg EM, Chen X, Xu X, Leuzzi G, et al.
Mol Cell. 2022 Oct 20;82(20):3901-3918.e7. doi:10.1016/j.molcel.2022.09.007
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.
Taglialatela A, Leuzzi G, Sannino V, Cuella-Martin R, et al.
Mol Cell. 2021 Oct 7;81(19):4008-4025.e7. doi:10.1016/j.molcel.2021.08.016
Functional interrogation of DNA damage response variants with base editing screens.
Cuella-Martin R, Hayward SB, Fan X, Chen X, Taglialatela A, Leuzzi G, et al.
Cell. 2021 Feb 18;184(4):1081-1097.e19. doi:10.1016/j.cell.2021.01.041
HATtracting Nucleases to Stalled Forks.
Leuzzi G, Taglialatela A, Ciccia A.
Mol Cell. 2020 Oct 15;80(2):177-180. doi:10.1016/j.molcel.2020.09.031
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease.
Joseph SA, Taglialatela A, Leuzzi G, Huang JW, Cuella-Martin R, Ciccia A.
DNA Repair (Amst). 2020 Nov;95:102943. doi:10.1016/j.dnarep.2020.102943
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.
Huang JW, Acharya A, Taglialatela A, Nambiar TS, Leuzzi G, et al.
Nat Commun. 2020 Jun 11;11(1):2948. doi:10.1038/s41467-020-16718-3
Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant.
Nambiar TS, Billon P, Diedenhofen G, Taglialatela A, Leuzzi G, et al.
Nat Commun. 2019 Jul 30;10(1):3395. doi:10.1038/s41467-019-11105-z
The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection.
Billing D, Horiguchi M, Wu-Baer F, Taglialatela A, Leuzzi G, et al.
Mol Cell. 2018 Oct 4;72(1):127-139.e8. doi:10.1016/j.molcel.2018.08.016
CSA and CSB play a role in the response to DNA breaks.
Pascucci B, Fragale A, Marabitti V, Leuzzi G, et al.
Oncotarget. 2018 Jan 29;9(14):11581-11591. doi:10.18632/oncotarget.24342
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Taglialatela A, Alvarez S, Leuzzi G, Sannino V, et al.
Mol Cell. 2017 Oct 19;68(2):414-430.e8. doi:10.1016/j.molcel.2017.09.036
WRNIP1: A new guardian of genome integrity at stalled replication forks.
Leuzzi G, Marabitti V, Pichierri P, Franchitto A.
Mol Cell Oncol. 2016 Aug 3;3(5):e1215777. doi:10.1080/23723556.2016.1215777
Crosstalk between mismatch repair and base excision repair in human gastric cancer.
Simonelli V, Leuzzi G, Basile G, D'Errico M, et al.
Oncotarget. 2016 Jun 20;8(49):84827-84840. doi:10.18632/oncotarget.10185
WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress.
Leuzzi G, Marabitti V, Pichierri P, Franchitto A.
EMBO J. 2016 Jul 1;35(13):1437-51. doi:10.15252/embj.201593265
Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress.
Basile G, Leuzzi G, Pichierri P, Franchitto A.
Nucleic Acids Res. 2014 Nov 10;42(20):12628-39. doi:10.1093/nar/gku1022
