IFOM Publications Giannino Del Sal
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Selected Publications Giannino Del Sal

  1. Bertolio R, Napoletano F, Del Sal G (2023)
    Dynamic links between mechanical forces and metabolism shape the tumor milieu.
    CURR OPIN CELL BIOL 2023 Oct; 84: 102218 doi.org/10.1016/j.ceb.2023.102218

  2. Camilla Tombari,Alessandro Zannini,Rebecca Bertolio,Silvia Pedretti,Matteo Audano,Luca Triboli, Valeria Cancila,Davide Vacca,Manuel Caputo,Sara Donzelli, Ilaria Segatto, Simone Vodret, Silvano Piazza, Alessandra Rustighi,Fiamma Mantovani,Barbara Belletti, Gustavo Baldassarre,Giovanni Blandino, Claudio Tripodo, Silvio Bicciato,Nico Mitro,Giannino Del Sal
    Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
    Nat Commun. 2023 Oct 25;14(1):6777. doi: 10.1038/s41467-023-42458-1.

  3. Napoletano, F., Ferrari Bravo, G., Voto, I.A.P., Santin, S., Celora, L., Campaner, E., Dezi, C., Bertossi, A., Valentino, E., Santorsola, M., Rustighi, A., Fajner, V., Maspero, E., Ansaloni, F., Cancila, V., Valenti, C.F., Santo, M., Artimagnella, O.B., Finaurini, S., Gioia, U., Polo, S., Sanges, R., Tripodo, C., Mallamaci, A., Gustincich, S., d’Adda di Fagagna, F., Mantovani, F., Specchia, V., Del Sal, G. (2021).
    The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
    Cell Reports 36, 109694.

  4. Valeria Capaci, Lorenzo Bascetta, Marco Fantuz, Galina V Beznoussenko, Roberta Sommaggio, Valeria Cancila, Andrea Bisso, Elena Campaner, Alexander A Mironov, Jacek R Wi?niewski, Luisa Ulloa Severino, Denis Scaini, Fleur Bossi, Jodi Lees, Noa Alon, Ledia Brunga, David Malkin, Silvano Piazza, Licio Collavin, Antonio Rosato, Silvio Bicciato, Claudio Tripodo, Fiamma Mantovani, Giannino Del Sal
    Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
    Nat Commun. 2020 Aug 7;11(1):3945. doi: 10.1038/s41467-020-17596-5.

  5. Fiamma Mantovani, Licio Collavin, Giannino Del Sal
    Mutant p53 as a guardian of the cancer cell
    Cell Death and Differentiantion 26,199-212 doi: /doi.org/10.1038/s41418-018-0246-9 (2019)

  6. Rebecca Bertolio, Francesco Napoletano, Miguel Mano, Sebastian Maurer-Stroh, Marco Fantuz, Alessandro Zannini, Silvio Bicciato, Giovanni Sorrentino, Giannino Del Sal
    Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
    Nature Communications 10, Article number: 1326 (2019)

  7. Caroli J, Sorrentino G, Forcato M, Del Sal G, Bicciato S. (2018)
    GDA, a web-based tool for Genomics and Drugs integrated analysis.
    Nucleic Acids Res.46(W1): W148-W156.doi: 10.1093/nar/gky434.

  8. Ingallina E, Sorrentino G, Bertolio R, Lisek K, Zannini A, Azzolin L, Severino LU, Scaini D, Mano M, Mantovani F, Rosato A, Bicciato S, Piccolo S, Del Sal G. (2018)
    Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis.
    Nat Cell Biol. 20(1):28-35. doi: 10.1038/s41556-017-0009-8.

  9. Liao P, Zeng SX, Zhou X, Chen T, Zhou F, Cao B, Jung JH, Del Sal G, Luo S, Lu H. (2017)
    Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding.
    Mol Cell. 68(6):1134-1146.e6. doi: 10.1016/j.molcel.2017.11.006.

  10. Valentino E, Bellazzo A, Di Minin G, Sicari D, Apollonio M, Scognamiglio G, Di Bonito M, Botti G, *Del Sal G, *Collavin L. (2017)
    Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP.
    Proc Natl Acad Sci U S A. 114(29):7623-7628. doi: 10.1073/pnas.1700996114. *co-corresponding author
    *co-corresponding author

  11. Campaner E, Rustighi A, Zannini A, Cristiani A, Piazza S, Ciani Y, Kalid O, Golan G, Baloglu E, Shacham S, Valsasina B, Cucchi U, Pippione AC, Lolli ML, Giabbai B, Storici P, Carloni P, Rossetti G, Benvenuti F, Bello E, D'Incalci M, Cappuzzello E, Rosato A, Del Sal G. (2017)
    A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.
    Nat Commun. 8:15772. doi: 10.1038/ncomms15772.

  12. Sorrentino G, Ruggeri N, Zannini A, Ingallina E, Bertolio R, Marotta C, Neri C, Cappuzzello E, Forcato M, Rosato A, Mano M, Bicciato S, Del Sal G. (2017)
    Glucocorticoid receptor signalling activates YAP in breast cancer.
    Nat Commun. 8:14073. doi: 10.1038/ncomms14073.

  13. Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, Rajkowska K, Gaweda-Walerych K, Ingallina E, Tonelli C, Morelli MJ, Amato A, Eterno V, Zambelli A, Rosato A, Amati B, Wi?niewski JR, Del Sal G. (2016).
    Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer.
    Nat Cell Biol 18(8):897-909. doi: 10.1038/ncb3380. PMID: 27347849.

  14. Di Agostino S, Sorrentino G, Ingallina E, Valenti F, Ferraiuolo M, Bicciato S, Piazza S, Strano S, *Del Sal G, *Blandino G. (2016).
    YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.
    EMBO Reports 17(2):188-20. doi: 10.15252/embr.201540488. PMID: 26691213. IF 9,05.
    *co-corresponding authors

  15. Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F. (2015).
    Notch is a direct negative regulator of the DNA-damage response.
    Nat Struct Mol Biol 22(5):417-24. doi: 10.1038/nsmb.3013. PMID: 25895060.

  16. Giorgi C, Bonora M, Sorrentino G, Missiroli S, Poletti F, Suski JM, Galindo Ramirez F, Rizzuto R, Di Virgilio F, Zito E, Pandolfi PP, Wieckowski MR, Mammano F, Del Sal G, Pinton P. (2015).
    p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner.
    Proc Natl Acad Sci USA 112(6):1779-84. doi: 10.1073/pnas.1410723112. PMID: 25624484.

  17. Di Minin G, Bellazzo A, Dal Ferro M, Chiaruttini G, Nuzzo S, Bicciato S, Piazza S, Rami D, Bulla R, Sommaggio R, Rosato A, Del Sal G, Collavin L. (2014).
    Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP.
    Mol Cell 56(5):617-29. doi: 10.1016/j.molcel.2014.10.013. PMID: 25454946.

  18. Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, Manfrin A, Ingallina E, Sommaggio R, Piazza S, Rosato A, Piccolo S, Del Sal G. (2014).
    Metabolic control of YAP and TAZ by the mevalonate pathway.
    Nat Cell Biol 16(4):357-66. doi: 10.1038/ncb2936. PMID: 24658687.

  19. Rustighi A, Zannini A, Tiberi L, Sommaggio R, Piazza S, Sorrentino G, Nuzzo S, Tuscano A, Eterno V, Benvenuti F, Santarpia L, Aifantis I, Rosato A, Bicciato S, Zambelli A, Del Sal G. (2014).
    Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.
    EMBO Mol Med 6(1):99-119. doi: 10.1002/emmm.201302909. PMID: 24357640.

  20. Steger M, Murina O, Hühn D, Ferretti LP, Walser R, Hänggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, Gerrits B, Del Sal G, Zerbe O, Sartori AA. (2013).
    Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection.
    Mol Cell 50(3):333-43. doi: 10.1016/j.molcel.2013.03.023. PMID: 23623683.

  21. Sorrentino G, Mioni M, Giorgi C, Ruggeri N, Pinton P, Moll U, Mantovani F, Del Sal G. (2013).
    The prolyl-isomerase Pin1 activates the mitochondrial death program of p53.
    Cell Death Differ 0(2):198-208. doi: 10.1038/cdd.2012.112. PMID: 22935610.

  22. Grison A, Mantovani F, Comel A, Agostoni E, Gustincich S, Persichetti F, Del Sal G. (2011).
    Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.
    Proc Natl Acad Sci USA 108(44):17979-84. doi: 10.1073/pnas.1106198108. PMID: 22011578.

  23. Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, Capaci V, Jordan L, Quinlan P, Thompson A, Mano M, Rosato A, Crook T, Scanziani E, Means AR, Lozano G, Schneider C, Del Sal G. (2011).
    A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
    Cancer Cell 20(1):79-91. doi: 10.1016/j.ccr.2011.06.004. PMID: 21741598.

  24. Lunardi A, Di Minin G, Provero P, Dal Ferro M, Carotti M, Del Sal G, Collavin L. (2010).
    A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.
    Proc Natl Acad Sci USA 107(14):6322-7. doi: 10.1073/pnas.1002447107. PMID: 20308539.

  25. Drost J, Mantovani F, Tocco F, Elkon R, Comel A, Holstege H, Kerkhoven R, Jonkers J, Voorhoeve PM, Agami R, Del Sal G. (2010).
    BRD7 is a candidate tumour suppressor gene required for p53 function.
    Nat Cell Biol 12(4):380-9. doi: 10.1038/ncb2038. PMID: 20228809.

  26. Rustighi A, Tiberi L, Soldano A, Napoli M, Nuciforo P, Rosato A, Kaplan F, Capobianco A, Pece S, Di Fiore PP, Del Sal G. (2009).
    The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer.
    Nat Cell Biol 11(2):133-42. doi: 10.1038/ncb1822. PMID: 19151708.

  27. Guida E, Bisso A, Fenollar-Ferrer C, Napoli M, Anselmi C, Girardini JE, Carloni P, Del Sal G. (2008).
    Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells.
    Cancer Res 68(16):6550-8. doi: 10.1158/0008-5472.CAN-08-0137. PMID: 18701478.

  28. Mantovani F, Tocco F, Girardini J, Smith P, Gasco M, Lu X, Crook T, Del Sal G. (2007).
    The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.
    Nat Struct Mol Biol 14(10):912-20. PMID: 17906639.

  29. Mantovani F, Piazza S, Gostissa M, Strano S, Zacchi P, Mantovani R, Blandino G, Del Sal G. (2004).
    Pin1 links the activities of c-Abl and p300 in regulating p73 function.
    Mol Cell 14(5):625-36. PMID: 15175157.

  30. Collavin L, Gostissa M, Avolio F, Secco P, Ronchi A, Santoro C, Del Sal G. (2004).
    Modification of the erythroid transcription factor GATA-1 by SUMO-1.
    Proc Natl Acad Sci USA 101(24):8870-5. PMID: 15173587.

  31. Zacchi P, Gostissa M, Uchida T, Salvagno C, Avolio F, Volinia S, Ronai Z, Blandino G, Schneider C, Del Sal G. (2002).
    The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
    Nature 419(6909):853-7. PMID: 12397362.