IFOM Pubblicazioni Vincenzo Costanzo
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Pubblicazioni Vincenzo Costanzo

  1. Srinivasan M, Scheinost JC, Petela NJ, Gligoris TG, Wissler M, Ogushi S, Collier JE, Voulgaris M, Kurze A, Chan KL, Hu B, Costanzo V, Nasmyth KA.
    The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.
    Cell. 2018 Apr 30. pii: S0092-8674(18)30508-7. doi: 10.1016/j.cell.2018.04.015. [Epub ahead of print]
    PMID: 29754816

  2. Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, Promonet A, Cribier A, Sarrazin A, Niedzwiedz W, Lopez B, Costanzo V, Krejci L, Chabes A, Benkirane M, Lin YL, Pasero P.
    SAMHD1 acts at stalled replication forks to prevent interferon induction.
    Nature. 2018 May;557(7703):57-61. doi: 10.1038/s41586-018-0050-1. Epub 2018 Apr 18.
    PMID: 29670289

  3. Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang JW, Madubata C, Anand R, Levy B, Rabadan R, Cejka P, Costanzo V, Ciccia A.
    Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
    Mol Cell. 2017 Oct 19;68(2):414-430.e8. doi: 10.1016/j.molcel.2017.09.036.
    PMID: 29053959

  4. Zadorozhny K, Sannino V, Belá? O, Ml?oušková J, Špírek M, Costanzo V, Krej?í L.
    Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection.
    Cell Rep. 2017 Oct 10;21(2):333-340. doi: 10.1016/j.celrep.2017.09.062.
    PMID: 29020621

  5. Bloom K, Costanzo V.
    Centromere Structure and Function.
    Prog Mol Subcell Biol. 2017;56:515-539. doi: 10.1007/978-3-319-58592-5_21.
    PMID: 28840251

  6. Kolinjivadi AM, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, Baldi G, Shen R, Ciccia A, Pellegrini L, Krejci L and Costanzo V.
    Smarcal1-mediated fork reversal triggers Mre11-dependent degradation of nascent DNA in the absence of Brca2 and stable Rad51 nucleofilaments.
    Mol Cell. 2017 Sep 7;67(5):867-881.e7. doi: 10.1016/j.molcel.2017.07.001. Epub 2017 Jul 27.

  7. Angelo Taglialatela, Silvia Alvarez Nanez, Giuseppe Leuzzi, Vincenzo Sannino, Lepakshi Ranjha, Jen-Wei Huang, Chioma Madubata, Brynn Levy, Raul Rabadan, Petr Cejka, Vincenzo Costanzo and Alberto Ciccia.
    Restoration of replication fork stability and genome integrity in BRCA1- and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers
    Mol Cell. 2017 Oct 19;70(5)

  8. Zadorozhny K, Sannino V, Belá? O, Ml?oušková J, Špírek M, Costanzo V*, Krej?í L*.
    Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection.
    Cell Rep. 2017 Oct 10;21(2):333-340. doi: 10.1016/j.celrep.2017.09.062
    (*Corresponding authors)

  9. Sannino V, Pezzimenti F, Bertora S, Costanzo V.
    Xenopus laevis as Model System to Study DNA Damage Response and Replication Fork Stability.
    Methods Enzymol. 2017;591:211-232

  10. Puddu F, Salguero I, Herzog M, Geisler NJ, Costanzo V, Jackson SP.
    Chromatin determinants impart camptothecin sensitivity.
    EMBO Rep. 2017 Apr 7

  11. Raspelli E, Falbo L, Costanzo V.
    Xenopus egg extract to study regulation of genome-wide and locus-specific DNA replication.
    Genesis. 2017 Jan;55(1-2). doi: 10.1002/dvg.22996. Review.

  12. Kolinjivadi AM, Sannino V, de Antoni A, Técher H, Baldi G, Costanzo V.
    Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.
    FEBS Lett. 2017 Jan 12. doi: 10.1002/1873-3468.12556. [Epub ahead of print] Review.

  13. Romeo F, Falbo L, Costanzo V.
    Replication, checkpoint suppression and structure of centromeric DNA.
    Nucleus. 2016 Nov;7(6):540-546. doi: 10.1080/19491034.2016.1255836. PMID: 27893298

  14. Sannino V, Kolinjivadi AM, Baldi G, Costanzo V.
    Studying essential DNA metabolism proteins in Xenopus egg extract.
    Int J Dev Biol. 2016;60(7-8-9):221-227.

  15. Sannino V, Costanzo V.
    ATR checkpoint suppression by repetitive DNA.
    Cell Cycle. 2016 Nov 16;15(22):2993-2994

  16. Simon AC, Sannino V, Costanzo V*, Pellegrini L*.
    Structure of human Cdc45 and implications for CMG helicase function.
    Nat Commun. 2016 May 18;7:11638. doi: 10.1038/ncomms11638.

  17. Aze A, Sannino V, Soffientini P, Bachi A, Costanzo V.
    Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression.
    Nat Cell Biol. 2016 Jun;18(6):684-91. doi: 10.1038/ncb3344.

  18. Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanovi? M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V*, Stracker TH*.
    GEMC1 is a critical regulator of multiciliated cell differentiation.
    EMBO J. 2016 May 2;35(9):942-60. doi: 10.15252/embj.201592821.

  19. Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F.
    Notch is a direct negative regulator of the DNA-damage response.
    Nat Struct Mol Biol. 2015 May;22(5):417-24. doi: 10.1038/nsmb.3013.

  20. Olivera Harris M, Kallenberger L, Artola Borán M, Enoiu M, Costanzo V, Jiricny J.
    Mismatch repair-dependent metabolism of O6-methylguanine-containing DNA in Xenopus laevis egg extracts.
    DNA Repair (Amst). 2015 Apr;28:1-7. doi: 10.1016/j.dnarep.2015.01.014.

  21. Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F.
    NCOA4 transcriptional coactivator inhibits activation of DNA replication origins.
    Mol Cell. 2014 Jul 3;55(1):123-37. doi: 10.1016/j.molcel.2014.04.031.

  22. Errico A, Aze A, Costanzo V.
    Mta2 promotes Tipin-dependent maintenance of replication fork integrity.
    Cell Cycle. 2014;13(13):2120-8. doi: 10.4161/cc.29157.

  23. Palazzo L, Della Monica R, Visconti R, Costanzo V, Grieco D.
    ATM controls proper mitotic spindle structure.
    Cell Cycle. 2014 Feb 6;13(7).

  24. Brown NJ, Marjanovi? M, Lüders J, Stracker TH, Costanzo V.
    Cep63 and cep152 cooperate to ensure centriole duplication.
    PLoS One. 2013 Jul 30;8(7).

  25. Aze A, Zhou JC, Costa A, Costanzo V.
    DNA replication and homologous recombination factors: acting together to maintain genome stability.
    Chromosoma. 2013 Oct;122(5):401-13. doi: 10.1007/s00412-013-0411-3. Epub 2013 Apr 16.

  26. Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C.
    A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy.
    Dev Cell. 2012 May 15;22(5):1001-16. Epub 2012 Apr 26.

  27. Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen KJ, Fachinetti D, Bermejo R, Cocito A, Costanzo V, Lopes M.
    Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
    Nat Struct Mol Biol. 2012 Mar 4;19(4):417-23. doi: 10.1038/nsmb.2258.

  28. Errico A, Costanzo V.
    Mechanisms of replication fork protection: a safeguard for genome stability.
    Crit Rev Biochem Mol Biol. 2012 May;47(3):222-35. Epub 2012 Feb 11.

  29. Lazzaro F, Novarina D, Amara F, Watt DL, Stone JE, Costanzo V, Burgers PM, Kunkel TA, Plevani P, Muzi-Falconi M.
    RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA.
    Mol Cell. 2012 Jan 13;45(1):99-110.

  30. Hashimoto Y, Puddu F, Costanzo V.
    RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks.
    Nat Struct Mol Biol. 2011 Dec 4;19(1):17-24. doi: 10.1038/nsmb.2177.

  31. Costanzo V.
    Brca2, Rad51 and Mre11: performing balancing acts on replication forks.
    DNA Repair (Amst). 2011 Oct 10;10(10):1060-5. Epub 2011 Sep 6. Review.

  32. Hashimoto Y, Costanzo V.
    Studying DNA replication fork stability in Xenopus egg extract.
    Methods Mol Biol. 2011;745:437-45.

  33. Cosentino C, Grieco D, Costanzo V.
    ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.
    EMBO J. 2011 Feb 2;30(3):546-55. Epub 2010 Dec 14.

  34. Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V.
    Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis.
    Nat Struct Mol Biol. 2010 Nov;17(11):1305-11. Epub 2010 Oct 10.

  35. Piergiovanni G, Costanzo V.
    GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication.
    Cell Cycle. 2010 Sep 15;9(18):3662-6.

  36. Balestrini A, Cosentino C, Errico A, Garner E, Costanzo V.
    GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication.
    Nat Cell Biol. 2010 May;12(5):484-91. Epub 2010 Apr 11.

  37. Errico A, Costanzo V.
    Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns.
    EMBO Rep. 2010 Apr;11(4):270-8. Epub 2010 Feb 26. Review.

  38. Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V.
    Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.
    EMBO J. 2009 Dec 2;28(23):3681-92. Epub 2009 Nov 5.

  39. Costanzo V, Chaudhuri J, Fung JC, Moran JV.
    Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair.
    EMBO Rep. 2009 Aug;10(8):837-42. Epub 2009 Jul 17. Review. No abstract available.

  40. Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V.
    Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.
    EMBO J. 2009 Dec 2;28(23):3681-92.

  41. Studying the DNA damage response using in vitro model systems.
    Garner E, Costanzo V.
    DNA Repair (Amst). 2009 Sep 2;8(9):1025-37.

  42. Garner E, Costanzo V.
    Studying the DNA damage response using in vitro model systems.
    DNA Repair (Amst). 2009 Sep 2;8(9):1025-37. Epub 2009 May 23. Review.

  43. Russo I, Cosentino C, Del Giudice E, Broccoletti T, Amorosi S, Cirillo E, Aloj G, Fusco A, Costanzo V, Pignata C.
    In ataxia-teleangiectasia betamethasone response is inversely correlated to cerebellar atrophy and directly to antioxidative capacity.
    Eur J Neurol. 2009 Jun;16(6):755-9.

  44. Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V.
    An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.
    Nat Cell Biol. 2009 Mar;11(3):278-85. Epub 2009 Feb 1.

  45. Takaki T, Trenz K, Costanzo V, Petronczki M.
    Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development.
    Curr Opin Cell Biol. 2008 Dec;20(6):650-60. Epub 2008 Nov 27. Review.

  46. Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A.
    HMGA1 protein is a novel target of the ATM kinase.
    Eur J Cancer. 2008 Nov;44(17):2668-79. Epub 2008 Sep 8.

  47. Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V.
    Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.
    EMBO J. 2008 Jul 23;27(14):1953-62. Epub 2008 Jul 3.

  48. Trenz K, Errico A, Costanzo V.
    Plx1 is required for chromosomal DNA replication under stressful conditions.
    EMBO J. 2008 Mar 19;27(6):876-85. Epub 2008 Feb 28.

  49. Errico A, Costanzo V, Hunt T.
    Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.
    Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14929-34. Epub 2007 Sep 10.

  50. Trenz K, Smith E, Smith S, Costanzo V.
    ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks.
    EMBO J. 2006 Apr 19;25(8):1764-74. Epub 2006 Apr 6.

  51. Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME.
    Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks.
    Mol Cell Biol. 2006 Jan;26(2):425-37.

  52. Shechter D, Costanzo V, Gautier J.
    Regulation of DNA replication by ATR: signaling in response to DNA intermediates.
    DNA Repair (Amst). 2004 Aug-Sep;3(8-9):901-8. Review.

  53. Shechter D, Costanzo V, Gautier J.
    ATR and ATM regulate the timing of DNA replication origin firing.
    Nat Cell Biol. 2004 Jul;6(7):648-55. Epub 2004 Jun 27.

  54. Costanzo V, Robertson K, Gautier J.
    Xenopus cell-free extracts to study the DNA damage response.
    Methods Mol Biol. 2004;280:213-27.

  55. Costanzo V, Paull T, Gottesman M, Gautier J.
    Mre11 assembles linear DNA fragments into DNA damage signaling complexes.
    PLoS Biol. 2004 May;2(5):E110. Epub 2004 May 11. Erratum in: PLoS Biol. 2004 Jun;2(6):876.

  56. Costanzo V, Gautier J.
    Xenopus cell-free extracts to study DNA damage checkpoints.
    Methods Mol Biol. 2004;241:255-67.

  57. Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J.
    An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.
    Mol Cell. 2003 Jan;11(1):203-13.

  58. Vitolo OV, Sant'Angelo A, Costanzo V, Battaglia F, Arancio O, Shelanski M.
    Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling.
    Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13217-21.

  59. D'Angiolella V, Costanzo V, Gottesman ME, Avvedimento EV, Gautier J, Grieco D.
    Role for cyclin-dependent kinase 2 in mitosis exit.
    Curr Biol. 2001 Aug 7;11(15):1221-6.

  60. Costanzo V, Robertson K, Bibikova M, Kim E, Grieco D, Gottesman M, Carroll D, Gautier J.
    Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.
    Mol Cell. 2001 Jul;8(1):137-47.

  61. Greenwood J, Costanzo V, Robertson K, Hensey C, Gautier J.
    Responses to DNA damage in Xenopus: cell death or cell cycle arrest.
    Novartis Found Symp. 2001;237:221-30; discussion 230-4. Review.

  62. Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M, Grieco D, Gautier J.
    Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.
    Mol Cell. 2000 Sep;6(3):649-59.

  63. Protein kinase A is required for chromosomal DNA replication.
    Costanzo V, Avvedimento EV, Gottesman ME, Gautier J, Grieco D.
    Curr Biol. 1999 Aug 26;9(16):903-6.
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